【p53 GST】重组人p53，GST标签,Recombin

【p53 GST】重组人p53，GST标签，Recombinant Human p53，p53

产品名称：【p53 GST】重组人p53，GST标签-Recombinant Human p53

产品货号：PRO-742

产品规格：10ug///2ug///5ug

来源宿主：大肠杆菌中重组表达

保存建议：【p53 GST】重组人p53，GST标签-Recombinant Human p53For long term storage store at -20℃.Avoid freeze/thaw cycles.

背景资料：Tumor protein p53 responds to various cellular stresses by regulating target genes that induce cell cycle arrest， apoptosis， senescence， DNA repair， or changes in metabolism. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth， replication， and apoptosis. p53 is a DNA-binding protein containing transcription activation， DNA-binding & oligomerization domains.p53 binds to mdm2， SV40 T antigen and human papilloma virus E6 protein p53 senses DNA damage and possibly facilitating repair. p53 protein is a transcription factor which is encoded in humans by the TP53 gene. Alterations of TP53 occur not only as somatic mutations in human malignancies， but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. p53 mutants that often occur in many different human cancers fail to bind the consensus DNA binding site， and hence cause the loss of tumor suppressor activity. Mutation involving p53 is found in a wide variety of malignant tumors， including breast， ovarian， bladder， colon， lung， and melanoma. The p53 expression in normal cells is low and in an assortment of transformed cell lines is high， which may contribute to transformation and malignancy. Multiple p53 variants encode distinct isoforms， which can regulate p53 transcriptional activity. p53’s significance in multicellular organisms is in cell cycle regulation therefore it functions as a tumor suppressor that is involved in preventing cancer. p53’s role in conserving stability by preventing genome mutation has earned it descriptions such as "the guardian of the genome，" "the guardian angel gene，" and the "master watchman.” The name p53 refers to its evident molecular mass: it migrates as a 53kDa protein on SDS-PAGE. However， based on calculations from its amino acid residues， p53’s mass is in fact only 43.7kDa. This difference is attributed to the high number of proline residues in the protein which slow its migration on SDS-PAGE， consequently making it appear larger than it actually is.

点击：【p53 GST】重组人p53，GST标签-Recombinant Human p53查看更详细产品说明，更多应用、储存、价格、货期等信息请致电垂询艾美捷科技有限公司。更多prospec公司特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看艾美捷特色产品中心。

ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司，具有20多年的生产经验，专注于蛋白（重组及合成）生产研发。我们的核心产品包括：干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。

艾美捷科技有限公司，通过提供完整的产品和服务体系、便利的客户关系和供应链管理，为生命科学研究工作者提供整体打包方案。我们的企业的核心价值观:“学习、创新、合作、卓越"。作为一家具有尖端的技术实力、的经营管理水平和完善的市场销售体系的生物高科技企业，总部位于武汉光谷高新技术开发区，服务面向全国。艾美捷科技是集进口试剂、实验室耗材销售、技术服务与合约开发为一体的专业化高科技公司，为用户提供最前沿的专业资讯、完备的产品、整合的解决方案，及优质的物流服务。为了更好的服务客户，公司组建了一支经验丰富的研发团队-艾美捷生物技术中心，进入研发生产阶段，将更优质的产品推荐给国内生物领域的同仁们!