【CSTB】重组人胱氨酸-B/【CSTB】重组人胱氨酸-B/

产品名称：【CSTB】重组人胱氨酸-B-Recombinant Human Cystatin-B

产品货号：PRO-609

产品规格：1mg///20ug///5ug

来源宿主：大肠杆菌中重组表达

保存建议：【CSTB】重组人胱氨酸-B-Recombinant Human Cystatin-B Stefin-B although stable 4℃ for 4 weeks， should be stored desiccated below -18℃.For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.Please prevent freeze-thaw cycles.

背景资料：Type 1 cystatins are also called stefins which function as intracellular thiol protease inhibitors. Cystatin-B protein is able to form a dimer stabilized by noncovalent forces， inhibiting papain and cathepsins l， h and b. CSTB protein protects proteases leakage from lysosomes. Mutations in Stefin-B gene cause primary defects in patients with progressive myoclonic epilepsy （EPM1）， a degenerative disease of the central nervous system. CSTB is overexpressed & elevated in the serum of HCC patients. Cystatin-B in vivo has a polymeric structure which is sensitive to the redox environment. Cystatin-B inhibits bone resorption by down-regulating intracellular cathepsin K activity despite increased osteoclast survival. Protein and mRNA levels of stefin B are significantly lower in atypical benign meningiomas. Stefins-A & Stefin-B which belong to the type-1 Cystatins， are up-regulated in lung tumours and thus able to counteract harmful tumour-associated proteolytic activity. Human stefin-A & Stefin-B form amyloid fibrils. Copper binding by stefin-B reduces amyloid fibril formation. A number of alternatively spliced CSTB isoforms were recognized in patients with progressive myoclonus epilepsy. Decreased CSTB activity in EPM1 pathogenesis is controled by cathepsins through increased activity of cathepsin-S & cathepsin-L.

点击：【CSTB】重组人胱氨酸-B-Recombinant Human Cystatin-B查看更详细产品说明，更多应用、储存、价格、货期等信息请致电垂询Prospec中国区域授权总代理艾美捷科技有限公司。更多特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看每日生物评论网站。

以色列ProSpec-Tany公司专注于细菌来源重组蛋白质生产。其独有细菌和哺乳动物表达和蛋白折叠技术使其成为闻名中外科研级蛋白供应商。ProSpec-Tany是海内上能提供蛋白种类很多公司之一。领先生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。作为多家知名品牌代理，艾美捷与ProSpec一起为研究者们提供优质、全新细胞生物学研究工具而不断扩大产品及服务质量。

艾美捷科技有限公司，通过提供完整的产品和服务体系、便利的客户关系和供应链管理，为生命科学研究工作者提供整体打包方案。我们的企业的核心价值观：“激情、敬业、学习、创新、合作、卓越”。激发我们内在的创造力，提供有竞争力的生物医学产品和服务，持续为客户创造很大价值是我们的企业使命。我们的企业愿景是成为受人尊重、世界知名的生物医学产品及服务供应商。艾美捷科技与国内外优秀的生物试剂供应商保持着密切的合作关系，目前已成为众多国际知名品牌的中国总代理或一级代理，主要包括：AmyJet、AAT Bioquest、Abnova、Agrisera、Biovision、Biosensis、Cayman Chemical、Caisson Labs、Cytoskeleton、CytoNiChe、Epigentek、Equitech-Bio、Hycult Biotech、Jackson、LifeSensors、ProSpec、Norgen Biotek、Mabtech、Matreya、iRegene、StressMarq、ImmunoReagents、SouthernBiotech、Origene、US Biological、Solis BioDyne等，可以在第一时间为用户提供很前沿的专业资讯、完备的产品及物流服务。艾美捷服务升级，全方位实验服务项目上线啦~

关键词：Recombinant Human Cystatin-B，【CSTB】重组人胱氨酸-B，CSTB