【A2M】人a-2巨球蛋白/【A2M】人a-2巨球蛋白/【A

产品名称：【A2M】人a-2巨球蛋白-Human Alpha-2 Macroglobulin Protein

产品货号：PRO-551

产品规格：10mg///1mg///200ug

来源宿主：人血浆中提取纯化

保存建议：【A2M】人a-2巨球蛋白-Human Alpha-2 Macroglobulin ProteinHuman Alpha-2 Macroglobulin although stable at room temperature for 3 weeks， should be stored between 2-8℃.

背景资料：Alpha-2 Macroglobulin is a serine proteases inhibitor， which inhibits coagulation by inactivating thrombin and Kallikrein， it inhibits fibrinolysis by inactivating plasmin and involved in insulin transport. Alpha-2-Macroglobulin is a large plasma protein， which is produced by the liver， it’s composed of 4 identical subunits bound together by -S-S- bonds. A2M is able to inactivate many kinds of proteinases （including serine-， cysteine-， aspartic- and metalloproteinases）. ?2M has a 35 amino acid "bait" region in its structure. Proteinases bind and cleave the “bait” region become bound to ?2M. Macrophage receptors recognize the proteinase-?2M complex and clear it from the system. A2M binds to and removes MMP-2 and MMP-9 （active forms of the gelatinase） from the circulation using scavenger receptors on the phagocytes. The levels of Alpha-2-macroglobulin are increased in nephrotic syndrome which is a condition where the kidneys start to leak out some of the smaller blood proteins. Due to its large size， ?2-macroglobulin is retained in the bloodstream. Increased production of all proteins causes ?2-macroglobulin concentration to increase. Chronic renal failure might lead to amyloid by alpha-2-macroglobulin. A2M is raised in cirrhosis， pregnancy and diabetes.

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关键词：Human Alpha-2 Macroglobulin Protein，【A2M】人a-2巨球蛋白，A2M