XZ739,2365172-19-4

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XZ739

CAS No. : 2365172-19-4

MCE 国际站：XZ739

产品活性：XZ739 是一种基于 Cereblon 的 PROTAC BCL-XL (Bcl-2 家族成员) 降解剂，作用于 MOLT-4 细胞，处理 16 小时后，DC₅₀ 值为 2.5 nM。XZ739 还通过 caspase 介导的凋亡 (apoptosis) 诱导细胞死亡。

研究领域：PROTAC  |  Apoptosis

作用靶点：PROTACs  |  Bcl-2 Family  |  Apoptosis

In Vitro: XZ739 (0.001-10 μM; 48 hours) potently reduces the viability of T-ALL MOLT-4, B-ALL RS4; 11, SCLC NCI-H146? cells, and platelets after 48 h treatment with IC₅₀s of 10.1, 41.8, 25.3, and 1217 nM, respectively. XZ739 has >100-fold selectivity for MOLT-4 cells over human platelets.
?XZ739 (1.2-300 nM; 16 hours) induces BCL-XL degradation in MOLT-4 cells.
?The BCL-XL degradation induced by XZ739 in MOLT-4 is rapid, starting within 2 h; and 8 h after XZ739 treatment, more than 96% of the BCL-XL is degraded with 100 nM of XZ739.

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