- ￥600 - 1000
- 仕诺达
- 安徽
- SND-639
- 2025年08月26日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
2-8℃
- 保质期：
详见产品说明
- 英文名：
Isoorientin
- 库存：
999
- 供应商：
仕诺达生物
- CAS号：
4261-42-1
- 规格：
10mg，分析标准品,HPLC≥98%（多种规格可选）/20mg，分析标准品,HPLC≥98%
| 规格： | 10mg，分析标准品,HPLC≥98%（多种规格可选） | 产品价格： | ￥600.0 |
|---|---|---|---|
| 规格： | 20mg，分析标准品,HPLC≥98% | 产品价格： | ￥1000.0 |
| 中文名 | 异荭草苷 |
| 英文名 | Isoorientin |
| 别名 | 异红草素 异荭草素 异荭草苷 异荭草素, 来源于荭草 木犀草素-6-C-葡萄糖苷 异荭草素,异荭草苷 ,异荭草素 木犀草素-6-C-葡萄糖苷(异荭草苷) 异荭草苷(异荭草素,异荭草苷 ,异荭草素) LUTEOLIN-6-C-GLUCOSIDE 异荭草苷 |
| 英文别名 | Isoorientin HOMOORIENTIN IsoorientinI Homoorientin lespecapittoside HoMoorientin, froM PolygonuM orientale 2-(3,4-Dihydroxyphenyl)-6-β-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one 6-(β-D-Glucopyranosyl)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one (1S)-1,5-anhydro-1-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-6-yl]-D-glucitol 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]chromone |
| CAS | 4261-42-1 |
| 化学式 | C21H20O11 |
| 分子量 | 448.38 |
| InChI | InChI=1/C21H20O11/c22-6-14-17(27)19(29)20(30)21(32-14)16-11(26)5-13-15(18(16)28)10(25)4-12(31-13)7-1-2-8(23)9(24)3-7/h1-5,14,17,19-24,26-30H,6H2/t14-,17-,19+,20-,21+/m1/s1 |
| InChIKey | ODBRNZZJSYPIDI-VJXVFPJBSA-N |
| 密度 | 1.759±0.06 g/cm3(Predicted) |
| 熔点 | 245-246°C |
| 沸点 | 856.7±65.0 °C(Predicted) |
| 比旋光度 | +18°（4.8mg/mL，methanol） |
| 闪点 | 303.2°C |
| 蒸汽压 | 2.9E-31mmHg at 25°C |
| 溶解度 | 甲醇: 可溶5mg/mL，澄清，无色至黄色 |
| 折射率 | 1.767 |
| 酸度系数 | 5.90±0.40(Predicted) |
| 存储条件 | 2-8°C |
| 稳定性 | 吸湿性 |
| 外观 | 粉末 |
| 颜色 | yellow |
| 物化性质 | 黄色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于竹叶，夏枯草，石竹。 |
| MDL号 | MFCD00017433 |
| 体外研究 | Isoorientin is a Selective Inhibitor of Cyclooxygenase-2 (COX-2) from the Tubers of Pueraria tuberosa. PANC-1 and PATU-8988 cells are grown for 24 hours in the presence of Isoorientin (0, 20, 40, 80, and 160 μM), and a CCK8 solution is added. The cell viability decreases significantly at the concentrations of 20, 40, 80, and 160 μM. After the cells are cultured with Isoorientin (0, 20, 40, 80, and 160 μM for PANC-1; 0, 20, 40, 80, 160, and 320 μM for PATU-8988) for 24 hours, the expression of p-AMPK and AMPK is assessed by Western blotting. After the Isoorientin treatment, the p-AMPK expression is increased. Then, in the shRNA group, the concentration of 80 μM is used to detect the effects of Isoorientin. The expression levels of AMPK and p-AMPK are much lower in the shRNA group than in the wild-type PC cells (WT) and the group that is transfected with a negative control lentivirus (NC). |
| 体内研究 | Animals treated with Isoorientin at 10 mg/kg and 20 mg/kg body weight have a statistically significant reduction in paw edema, with a mean peak thickness of 1.19±0.05 mm and 1.08±0.04 mm, respectively. This indicated that Isoorientin significantly attenuates paw edema compared with the control group. |
计算化学数据：
- 分子量：448.3769g/mol
- 化合物是否规范：True
- 疏水参数计算参考值（XLogP3-AA）：-0.2
- 准确质量：448.10056145
- 同位素质量：448.10056145
- 复杂度：729
- 可旋转化学键数量：3
- 氢键供体数量：8
- 氢键受体计数：11
- 拓扑极表面积：197
- 重原子数量：32
- 确定原子立构中心数量：5
- 不确定原子立构中心数量：0
- 确定化学键立构中心数量：0
- 不确定化学键立构中心数量：0
- 同位素原子计数：0
- 共价键单元数量：1
- CACTVS Substructure Key Fingerprint：AAADceB4PAAAAAAAAAAAAAAAAAAAAAAAAAA0YIEAAAAAAACBQAAAGgAACAAADBSgmAIwBoAABgCIAqBSAAACCAAkIAAIiAEGiMgNNzaGNRqCeWGl4BULuQfI7PzOIAADCAAIQABAAAYQABCAAAAAAAAAAA==
■针对客户购买情况公司有不同的优惠折扣，欢迎咨询订购~
■郑重申明：本公司销售所有产品均为实物拍摄，如产品出现质量问题，本公司包一切售后！！！
■500元以上包邮，本公司提供正规发票，货到付款，可按科研实验要求定制产品！！！
■本公司已与很多高校中科院及研发单位合作并也获得了老师的认可和推荐！！！ 
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验1. 雁南 贺子君 刘刚. 响应面法优化荭草异荭草素提取工艺[J]. 北方园艺 2020 000(007):124-131.
2. 杨燕梅. UPLC法测定7种秦艽中7种指标成分的量[J]. 中草药 2016 Vol.47Issue(11):1968-1973.
3. 卢有媛, 张小波, 杨燕梅,等. 秦艽药材的品质区划研究[J]. 中国中药杂志, 2016, 41(017):3132-3138.
4. 张永, 冯语婷, 马宁辉,等. 竹叶提取工艺的综合性评价[J]. 中国实验方剂学杂志, 2018(17).
5. 杨燕梅, 马晓辉, 吕培霖,等. 野生与栽培黄管秦艽7种指标成分的比较研究[J]. 中国药房, 2016, 27(19):2618-2621.
6. 罗林云, 杨燕梅, 晋玲. 青海与甘肃小秦艽7种指标成分含量的比较研究[J]. 中国医院药学杂志, 2017, 37(008):717-721.
7. 杨燕梅, 黄得栋, 卢有媛,等. 黄管秦艽UPLC指纹图谱研究[J]. 中药材, 2016, 39(008):1734-1737.
8. 郭静 王浩然 沈周媛 张彤 袁秀荣 丁越.3种竹叶抗氧化有效成分分析[J].中成药 2019 41(11):2688-2694.
9. 王伟,何平,江小明.木犀草素及其黄酮苷的抗炎、抗氧化作用[J].食品科学,2020,41(17):208-215.
10. Zhang, G. , et al. "Antinociceptive effect of isoorientin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve in mice." International Immunopharmacology 75(2019):105753-.DOI： 10.1016/j.intimp.2019.105753
11. Wang, Chu-Yang, et al. "Isolation of wheat mutants with higher grain phenolics to enhance anti-oxidant potential." Food chemistry 303 (2020): 125363
12. [IF=5.279] Yong Sun et al."Qualitative and Quantitative Analysis of Phenolics in Tetrastigma hemsleyanum and Their Antioxidant and Antiproliferative Activities."J Agr Food Chem. 2013;61(44):10507–10515
13. [IF=7.514] Chu-Yang Wang et al."Isolation of wheat mutants with higher grain phenolics to enhance anti-oxidant potential."Food Chem. 2020 Jan;303:125363
14. [IF=5.396] Mingfang Tao et al."Flavonoids from the mung bean coat promote longevity and fitness in Caenorhabditis elegans."Food Funct. 2021 Aug;12(17):8196-8207
15. [IF=2.19] Sheng-xiang Yang et al."Extraction of flavonoids from Cyclocarya paliurus (Juglandaceae) leaves using ethanol/salt aqueous two-phase system coupled with ultrasonic."J Food Process Pres. 2020 Jun;44(6):e14469
16. [IF=2.863] Xiaokang Liu et al."Spectrum–effect relationship between ultra-high-performance liquid chromatography fingerprints and antioxidant activities of Lophatherum gracile Brongn."Food Science & Nutrition. 2022 Feb 22
17. [IF=3.373] Yiyuan Luo et al."Quality evaluation of Tetrastigma hemsleyanum different parts based on quantitative analysis of 42 bioactive constituents combined with multivariate statistical analysis."PHYTOCHEMICAL ANALYSIS. 2022 Apr 05
18. [IF=7.514] Jie Meng et al."Conduction of a chemical structure-guided metabolic phenotype analysis method targeting phenylpropane pathway via LC-MS: Ginkgo biloba and soybean as examples."FOOD CHEMISTRY. 2022 Oct;390:133155
19. [IF=6.576] Junkun Pan et al."Inhibition of Dipeptidyl Peptidase-4 by Flavonoids: Structure–Activity Relationship, Kinetics and Interaction Mechanism."Frontiers in Nutrition. 2022; 9: 892426
