PD-1/PDCD1, Human Recombinant/

产品名称：PD-1 / PDCD1，人类重组/PD-1 / PDCD1，人类重组/PD-1 / PDCD1，人类重组-PD-1/PDCD1, Human Recombinant/PD-1/PDCD1, Human Recombinant/PD-1/PDCD1, Human Recombinant

产品货号：P1024-10

产品规格：10ug

来源宿主：待更新

保存建议：PD-1 / PDCD1，人类重组/PD-1 / PDCD1，人类重组/PD-1 / PDCD1，人类重组-PD-1/PDCD1, Human Recombinant/PD-1/PDCD1, Human Recombinant/PD-1/PDCD1, Human Recombinant-20°C

背景资料：Programmed death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer. This protein is suitable for use in protein studies such as protein structure analysis and protein-protein interactions. It can also be used as an immunogen, as a protein standard, or in cell biology research applications.

点击：PD-1 / PDCD1，人类重组/PD-1 / PDCD1，人类重组/PD-1 / PDCD1，人类重组-PD-1/PDCD1, Human Recombinant/PD-1/PDCD1, Human Recombinant/PD-1/PDCD1, Human Recombinant查看更详细产品说明，更多应用、储存、价格、货期等信息请致电垂询BioVision中国区域授权总代理艾美捷科技有限公司。更多特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看每日生物评论网站。

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