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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃.
- 保质期:
Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
- 英文名:
Recombinant Human T-cell surface glycoprotein CD1c (CD1C), partial
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 规格:
20μg
英文名称:
Recombinant Human T-cell surface glycoprotein CD1c (CD1C), partial品名简称:
Recombinant Human CD1C protein, partial货号:
CSB-YP004891HU规格:
20μg价格:
2208LC-MS/Western Blot:
/SDS-PAGE:
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.纯度:
Greater than 90% as determined by SDS-PAGE.内毒素:
Not test生物活性:
/基因名:
CD1CUniprot No.:
P29017别名:
BDCA1; CD1; CD1A; CD1c; CD1c antigen; CD1C antigen c polypeptide; CD1c molecule; CD1C_HUMAN; Cortical thymocyte antigen CD1C; Differentiation antigen CD1 alpha 3; R7; T cell surface glycoprotein CD1c; T-cell surface glycoprotein CD1c种属:
Homo sapiens (Human)蛋白长度:
Extracellular Domain来源:
Yeast分子量:
34.2 kDa表达区域:
18-302aa氨基酸序列:
NADASQEHVSFHVIQIFSFVNQSWARGQGSGWLDELQTHGWDSESGTIIFLHNWSKGNFSNEELSDLELLFRFYLFGLTREIQDHASQDYSKYPFEVQVKAGCELHSGKSPEGFFQVAFNGLDLLSFQNTTWVPSPGCGSLAQSVCHLLNHQYEGVTETVYNLIRSTCPRFLLGLLDAGKMYVHRQVRPEAWLSSRPSLGSGQLLLVCHASGFYPKPVWVTWMRNEQEQLGTKHGDILPNADGTWYLQVILEVASEEPAGLSCRVRHSSLGGQDIILYWGHHFSM蛋白标签:
N-terminal 6xHis-tagged产品提供形式:
Liquid or Lyophilized powder缓冲液:
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.储存条件:
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.保质期:
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.货期:
25-35 business days注意事项:
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.功能1:
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.功能2:
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.文献:
"Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens."Briken V., Jackman R.M., Watts G.F.M., Rogers R.A., Porcelli S.A.J. Exp. Med. 192:281-288(2000) .研究领域:
Immunology请点击“在线询价”找客服索取产品说明书及引用文献目录,产品实时更新参数、价格信息、更多文献信息可以查看cusabio官网
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文献和实验CD1a/CD1b/CD1c/CD1d分子 CD1a 常用单克隆抗体或代号:T6,Leu6 主要表达细胞:Thy,DCsub,LHC,Bsub T细胞 分子质量(kDa)和结构:gp49(IgSF) 功 能:与β2m组成MHCI类样分子,有抗原提呈功能 CD1b 常用单克隆抗体或代号:WM-25,4A7.6,NUT2 主要表达细胞:Thy,DC,LHC,Bsub T细胞 分子
Nature Medicine 再论多重免疫荧光揭示预测性生物标志物,用于优化免疫治疗临床试验设计
特征和生存率间关系 在 TLS 结构之外,治疗应答者和非应答者之间最显著差异表达的基因是那些编码免疫球蛋白,特别是免疫球蛋白 G(IgG)的基因。多色免疫荧光标记肿瘤内的 CD83、CD1c、CD11c、CD68、HLA-DRA、DAPI 对比应答者和非应答者的 TLS,显示非应答者中幼稚 B 细胞的浸润程度更高。 多重免疫荧光验证抗原呈递细胞肿瘤浸润与 TLS 阳性肉瘤患者的抗 PD-1 反应有关 为了可视化应答者和非应答者之间免疫细胞丰度的差异,研究者开发了三个六色免疫荧光方案,能够
杆菌源的。这表明,这些分子特异地结合并提呈特异脂类给分支杆菌,因此,在对结核分支杆菌和麻风病免疫中起了特殊作用。分支杆菌的阿拉伯甘露聚糖脂(LAM),甘露聚糖脂,自由分支菌酸,葡萄糖单分支菌和磷脂酰胆碱甘露糖苷(PIM),都是CD1b的配体。分支杆菌二酯酰硫化糖苷(SGL),例如Ac2SGL带有两个棕榈酸链,已经加入到这个行列中。CD1c提呈菌源的甘露糖磷酸类异戊二烯给T细胞,识别微生物配体给CD1a—一类分枝杆菌脂肽(二羟分枝杆菌)。α-半乳糖苷神经酰胺(未知生理意义的海绵脂)结合CD1d并对Vα
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