- 询价
- Agrisera
- 瑞典
- AS16 4000
- 2025年10月21日
- 1-10 µg/ml (WB) The optimal working dilution should be determined by the investigator.
- Mouse
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Human p21 protein. UniProt: P38936
- 亚型：
IgG1
- 形态：
Liquid
- 保存条件：
Store at -20°C.
- 克隆性：
Monoclonal
- 适应物种：
Human
- 抗原来源：
P38936
- 级别：
分子生物学级
- 供应商：
Agrisera
- 宿主：
Mouse
- 应用范围：
1-10 µg/ml (WB) The optimal working dilution should be determined by the investigator.
- 靶点：
The expression of p21 is mostly induced by p53, usually in response to DNA damage induced by cytotoxic agents. p21 interrupts the cell cycle and prevents the replication of the cell containing genomic errors. p21 also inhibits Cdk2, Cdk3, Cdk4 and Cdk6 to
- 抗体名：
p21 WAF-1 (clone WA-1)
- 规格：
100 µg
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文献和实验CIP/WAF gene without binding DNA directly but through interaction with different transcription factors such as Sp1 and Miz-1 that recognize specific DNA sequences in the p21CIP/WAF promoter (Gartel et al., 2001 and Wu e al., 2003). N-Myc
involved in deposition of an extracellular matrix (ECM), such as fibronectin and its receptor, collagen and collagenase (5 –9 ), the proto-oncogene products c-Jun and JunB (10 –12 ), the cell-cycle regulators p15 and p21 /Waf/Cip (13 –15
WAF1和DNMT1与细胞增殖核抗原（PCNA）同一区域的结合情况。DNMT1与PCNA的结合在细胞周期后S期将DNMT1靶向复制复合物中起重要作用。体外试验显示源于p21WAF1的寡肽能高效抑制DNMT1-PCNA形成[9]。尽管正常结肠上皮细胞中DNMT1和p21WAF的表达互相排斥，但腺息肉（adenomatous polyps）中表达DNMT细胞也表达p21WAF，且p21WAF在乳癌、肺癌、卵巢癌和肝细胞癌的早期阶段高度表达。p21WAF在肿瘤发生早期高表达，替代DNMT1形成复制复合
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