Sst/Sst蛋白Recombinant Mouse Som

纯度：

Greater than 85% as determined by SDS-PAGE.

基因名：

Sst

Uniprot No.：

P60041

别名：

(NST)

种属：

Mus musculus (Mouse)

蛋白长度：

Partial

来源：

E.coli

分子量：

18.5 kDa

表达区域：

89-116aa

氨基酸序列：

SANSNPAMAPRERKAGCKNFFWKTFTSC

蛋白标签：

N-terminal 6xHis-KSI-tagged

产品提供形式：

Liquid or Lyophilized powder

缓冲液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

货期：

3-7 business days

注意事项：

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

功能：

[Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin. ; [Neuronostatin]: May enhance low-glucose-induced glucagon release by pancreatic alpha cells. This effect may be mediated by binding to GPR107 and PKA activation. May regulate cardiac contractile function. May compromise cardiomyocyte viability. In the central nervous system, may impair memory retention and may affect hippocampal excitability. May also have anxiolytic and anorexigenic effects. May play a role in arterial pressure regulation. May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH.

内毒素：

Not test.

SDS-PAGE:

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

LC-MS Image Description/Western Blot:

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Product types:

In Stock Protein

Biological_Activity:

/

Research Areas:

Cancer

Reconstitution:

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Reference:

"Neuronostatin encoded by the somatostatin gene regulates neuronal, cardiovascular, and metabolic functions." Samson W.K., Zhang J.V., Avsian-Kretchmer O., Cui K., Yosten G.L., Klein C., Lyu R.M., Wang Y.X., Chen X.Q., Yang J., Price C.J., Hoyda T.D., Ferguson A.V., Yuan X.B., Chang J.K., Hsueh A.J. J. Biol. Chem. 283:31949-31959(2008)

Function:

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