Toll-Like Receptor 7 (TLR7) (I

Toll-Like Receptor-Dependent Immune Complex Activation of B Cells and Dendritic Cells

High titers of autoantibodies reactive with DNA/RNA molecular complexes are characteristic of autoimmune disorders such as systemic lupus erythematosus (SLE). In vitro and in vivo studies have implicated Toll-like receptor 9 (TLR9) and Toll-like

Characterisation of Viral Proteins that Inhibit Toll-Like Receptor Signal Transduction

Toll-like receptor (TLR) signalling involves five TIR adapter proteins, which couple to downstream protein kinases that ultimately lead to the activation of transcription factors such as nuclear factor-κB (NF-κB) and members of the interferon

Deciphering the Code of Innate Immunity Recognition of siRNAs

delivery of siRNAs into blood cells is often accompanied by the activation of immunity. Recent studies indicated that certain siRNA sequences engage Toll-like receptor TLR7/8 signalling resulting in the activation of a large number of host defense genes