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- 2025年07月16日
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- 保存条件：
-20℃
- 克隆性：
单克隆
- 抗体名：
Toll-Like Receptor 7 (TLR7) (N-Term) 抗体
- 规格：
0.1ml/0.2ml
Toll-Like Receptor 7 (TLR7)
别名 TLR7A, TLR7-like, RGD1563357
抗原表位
其他选择 N-Term
适用
其他选择 人, 小鼠
宿主
其他选择 兔
克隆类型
多克隆
标记
其他选择 非结合性
应用范围
其他选择 酵素免疫分析法（EIA）, Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), 免疫组织化学石蜡技术（IHC-P）
Pubmed 2个引用可参考
规格 0.4 mL
发货至 中国 (更改)
发货时间 29至35个工作日
产品编号 yb357057
产品细节 Toll-Like Receptor 7 (TLR7) (N-Term) 抗体
免疫原 This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-term region of human TLR7.
亚型 Ig
特异性 This antibody detects TLR7 at N-term.
交叉反应 （详细） Species reactivity (tested):Human and Mouse.
纯化方法 Protein Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
目标详细情况 Toll-Like Receptor 7 (TLR7) (N-Term) 抗体
别名 TLR7
背景 The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR7 is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X.Synonyms: Toll-like receptor 7
分子量 120921 Da
基因ID 51284, 9606
UniProt Q9NYK1
研究领域 Immunology, Innate Immunity, Transcription Factors, Signaling, Inflammation
使用细节Toll-Like Receptor 7 (TLR7) (N-Term) 抗体
应用备注 ELISA: 1/1,000. Western blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
贮存及处理Toll-Like Receptor 7 (TLR7) (N-Term) 抗体
状态 Liquid
浓度 0.25 mg/mL
缓冲液 PBS with 0.09 % (W/V) Sodium Azide as preservative
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freezing and thawing.
储存条件 4 °C/-20 °C
储存方法 Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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文献和实验Toll-Like Receptor-Dependent Immune Complex Activation of B Cells and Dendritic Cells
High titers of autoantibodies reactive with DNA/RNA molecular complexes are characteristic of autoimmune disorders such as systemic lupus erythematosus (SLE). In vitro and in vivo studies have implicated Toll-like receptor 9 (TLR9) and Toll-like
Biomarkers Measuring the Activity of Toll-Like Receptor Ligands in Clinical Development Programs
Efforts to develop therapeutic approaches based on stimulation of Toll-like receptor (TLR) pathways have increased in recent years (Nat Med 13:552–559). The effectiveness of TLR agonists is currently being tested in diseases such as cancer
Methods and protocols for automated synthesis and purification of immune modulatory oligonucleotides (IMOs), a novel class of Toll-like receptor 9 (TLR9) agonists, are described. IMOs containing two short identical sequences of 11-mers
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