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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃.
- 保质期:
Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
- 英文名:
Recombinant Human Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMGCS2)
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 规格:
20μg
英文名称:
Recombinant Human Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMGCS2)品名简称:
Recombinant Human HMGCS2 protein货号:
CSB-EP010567HU规格:
20μg价格:
1536LC-MS/Western Blot:
/SDS-PAGE:
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.纯度:
Greater than 90% as determined by SDS-PAGE.内毒素:
Not test生物活性:
/基因名:
HMGCS2Uniprot No.:
P54868别名:
HMG-CoA synthase;3-hydroxy-3-methylglutaryl coenzyme A synthase种属:
Homo sapiens (Human)蛋白长度:
Full Length of Mature Protein来源:
E.coli分子量:
59.8 kDa表达区域:
38-508aa氨基酸序列:
TASAVPLAKTDTWPKDVGILALEVYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALERGLRGTHMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFTLDDLQYMIFHTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKASQDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARRPV蛋白标签:
N-terminal 10xHis-tagged and C-terminal Myc-tagged产品提供形式:
Liquid or Lyophilized powder缓冲液:
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.储存条件:
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.保质期:
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.货期:
13-23 business days注意事项:
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.功能1:
Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate.功能2:
/文献:
/研究领域:
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文献和实验Lysosomal Acid Lipase: Assay and Purification
of intracellular lipid metabolism by three mechanisms: (1) free cholesterol reduces the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA)-reductase, the key enzyme of cholesterol synthesis (4 ) (2) cholesterol activates its own esterification by acyl-CoA
脂症。尤其对家族性Ⅲ型高血脂症效果更好。也可用于消退黄色瘤。对HDL-c下降的轻度高胆固醇血症也有较好疗效。 【不良反应】苯氧酸类药物不良反应较轻。有轻度腹痛、腹泻、恶心等胃肠道反应。偶有皮疹、脱发、视物模糊、血象异常等。 HMG-CoA还原酶抑制剂 HMG-CoA(3-羟基-3-甲基戊二酰辅酶A,3-hydroxy-3-methylglutaryl-coenzyme A)还原酶抑制剂最早是从霉菌培养液中提取,有美伐他汀(mevastatin)、乐伐他汀(lovastatin
-CoA还原酶抑制剂 HMG-CoA(3-羟基-3-甲基戊二酰辅酶A,3-hydroxy-3-methylglutaryl-coenzyme A)还原酶抑制剂最早是从霉菌培养液中提取,有美伐他汀(mevastatin)、乐伐他汀(lovastatin)、以后又有美伐他汀的羟基化、甲基化衍生物普伐他汀(pravastatin)、塞伐他汀(simvastatin)。美伐他汀药效弱而不良反应多,未用于临床。 【药理作用】能明显降低血浆TC和LDL-c.患者每天服用本类药物10~40
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