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文献和实验Phenylalanine Hydroxylase, Tyrosine Hydroxylase, and Tryptophan Hydroxylase
(tyrosine hydroxylase, TH, EC 1.14.16.2), anthranilate 3-monooxygenase (EC 1.14.16.3), and tryptophan 5-monooxygenase (tryptophan hydroxylase, TPH, EC 1.14.16.4). All four enzymes are also known as iron-proteins since they require iron for enzymatic actrvity
Measurement of Biopterin and the Use of Inhibitors of Biopterin Biosynthesis
4 through a two-step reduction of its side-chain carbonyl groups by sepiapterin reductase. Fig. 1. Proposed scheme for BH 4 metabolism. The reactions of tyrosine hydroxylase, tryptophan hydroxylase, and NOS are not shown. The route for the conversion
Neurotoxins that affect central indoleamine neurons
; Ungerstedt, 1971) and measurements of the activity of tryptophan hydroxylase and 5-HT uptake (Kuhar et al., 1972). This work was later complemented by anatomical descriptions of the now chemically identified neurotransmitter systems using radioautographic
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