产品名称:N-糖化乳糖基鞘氨醇-N-Glycinated lactosylsphingosine
产品货号:2090-1
产品规格:1mg
背景资料:固体
保存建议:N-糖化乳糖基鞘氨醇-N-Glycinated lactosylsphingosine对于本产品,我们推荐使用-20℃蓝冰低温进行运输。在您收到货物后,我们建议在-20℃温度下冷冻保存,溶解使用说明请参考本品说明。
产品描述:N-Glycinated lactosylsphingosine is an analogue of the important biomolecule lactosylsphingosine. It is ideal for use as an internal standard in the extraction and mass spectrometry analysis of lactosylsphingosine from natural samples.(1) The free amine group gives this product very similar physical characteristics to the natural glycosphingolipid while the glycine adds an additional 57 units to the molecule making it easy to detect by MS. Lactosylceramide is the precursor of many other glycosphingolipids and also functions as a second messenger and protein receptor, making it a very important biochemical. Many cellular processes are dependent on lactosylceramide since it is the substrate for neutral oligoglycosylceramides and gangliosides, all of which have their own vital functions. Lactosylceramide also helps to stabilize the lipid membrane, activate receptor molecules and act as a receptor for certain bacteria and toxins. In animals, where it is found mostly in epithelial and neuronal cells, it is expressed on neutrophils and macrophages, where it binds to toxins and bacteria, which are then engulfed and eliminated. It's role as a second messenger has been found to be vital and dysfunctions in its processes can lead to cancer and inflammation due to it being critical for neutrophil activity and in activating anti-inflammatory responses.(2) Therefore, it is being studied for its use in cancer therapies and as a therapy for other diseases. Other examples of lactosylceramide second messenger functions are tumor necrosis factor α and platelet-derived growth factor. Niemann-Pick Type C, a neurovisceral lysosomal cholesterol trafficking and lipid storage disorder, leads to an accumulation of multiple lipids, including excess unesterified cholesterol, GM2 and GM3 gangliosides, lactosylceramide, and glucosylceramide.(3) Lactosylceramide is also important in the activation of platelet/endothelial cell adhesion molecule-1 which causes adhesion and diapedesis of monocytes/lymphocytes.(4) In animals neutral lyso-glycosphingolipids occur naturally in small amounts. lyso-Lactosylceramide can release calcium stores from microsomes in the brain cortex and cerabellum.(5) Other lyso-glycosphingolipids also release calcium but in a mechanism different from lyso-lactosylceramide.
点击:N-糖化乳糖基鞘氨醇-N-Glycinated lactosylsphingosine查看更详细产品说明,更多应用、储存、价格、货期等信息请致电垂询Matreya中国区域授权总代理艾美捷科技有限公司。更多特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看每日生物评论网站。
Matreya LLC是一家脂质生化公司,致力于开发和制造高质量的脂质和生物化学品。Matreya在化学合成以及天然产物提取和纯化方面经验丰富,生产出的产品具有最佳纯度。 Matreya产品线包括一系列鞘脂、糖脂、鞘糖脂、脂肪酸和酯、甾醇和维生素E异构体(生育酚和生育三烯酚)。专长是生产高纯度鞘氨醇、神经酰胺、硫酸酯、神经节苷脂、酶抑制剂、生育酚和生育三烯酚。是全球提供脂质产品最全的供应商之一。产品涉及生物化学、制药、微生物学、食品和农业等研究领域。
艾美捷科技有限公司,通过提供完整的产品和服务体系、便利的客户关系和供应链管理,为生命科学研究工作者提供整体打包方案。我们的企业的核心价值观:“激情、敬业、学习、创新、合作、卓越”。激发我们内在的创造力,提供有竞争力的生物医学产品和服务,持续为客户创造最大价值是我们的企业使命。我们的企业愿景是成为受人尊重、世界一流的生物医学产品及服务供应商。艾美捷科技与国内外优秀的生物试剂供应商保持着密切的合作关系,目前已成为众多国际知名品牌的中国总代理或一级代理,主要包括:AmyJet、AAT Bioquest、Abnova、Agrisera、Biovision、Biosensis、Cayman Chemical、Caisson Labs、Cytoskeleton、CytoNiChe、Epigentek、Equitech-Bio、Hycult Biotech、Jackson、LifeSensors、ProSpec、Norgen Biotek、Mabtech、Matreya、iRegene、StressMarq、ImmunoReagents、SouthernBiotech、Origene、US Biological、Solis BioDyne等,可以在第一时间为用户提供最前沿的专业资讯、完备的产品及物流服务。艾美捷服务升级,全方位实验服务项目上线啦~
关键词:生化试剂,N-糖化乳糖基鞘氨醇,待更新