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文献和实验Fluorescence Polarization as an Early Measure of T-Lymphocyte Stimulation
in lymphocyte activation, transformation, mitosis, and finally apoptosis (1 –3 ). These events are associated with early changes in membrane potential, coupled with an Na+ influx, and with changes in pH, followed by the influx and internal release of Ca2+ ions
Directed Differentiation of Embryonic Stem Cells to the T-Lymphocyte Lineage
cells and B lymphocytes, while the expression of an appropriate Notch ligand, such as Delta-like 1, on OP-9 cells (OP9-DL1) is required to support the generation of T-cells in vitro. Here, we describe an updated and streamlined protocol
来自骨髓的多能性干细胞( plu - ripotent stem cell ),干细胞在某种刺激下,分化成淋巴球。干细胞或淋巴球的前躯细胞的一部分,通过血流输送到胸腺,在胸腺内分化成为胸腺细胞( thymocyte ),其一部分再分化,成为 T 淋巴细胞,分布在循环系及末梢淋巴系组织中。干细胞的一部分在鸟类的腔上囊( bursa of Fabricius )(在哺乳类与此相应的器官尚不清楚)内分化成为 B 淋巴细胞,定着于末梢淋巴系组织中,成为抗体产生细胞。
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