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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
100872-83-1
- 规格：
10 mM * 1 mL/2 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥898.0 |
|---|---|---|---|
| 规格： | 2 mg | 产品价格： | ￥600.0 |
| 规格： | 5 mg | 产品价格： | ￥990.0 |
| 规格： | 10 mg | 产品价格： | ￥1650.0 |
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ML346
CAS No. : 100872-83-1
MCE 国际站：ML346
产品活性：ML346是 Hsp70 和 HSF-1 活性的激活剂，针对 Hsp70 的 EC50 为 4.6 μM。ML346 恢复构象疾病模型中的蛋白质折叠，而没有明显的细胞毒性或缺乏特异性。ML346 诱导了热休克反应 (HSR) 的基因和蛋白质效应子的特异性增加，包括伴侣蛋白如 Hsp70，Hsp40 和 Hsp27。
研究领域：Cell Cycle/DNA Damage | Metabolic Enzyme/Protease
作用靶点：HSP
In Vitro: ML346 is an activator of Hsp70, with an EC50 of 4600 nM in HeLa cells. ML346 (10 μM) restores proteostasis, restores CFTR-mediated iodide conductance, and enhances the correct folding of proteins expressed in two different cellular compartments. ML346 (Compound F1) induces multiple responses and strongly induces Hsp70, the oxidative stress response genes (HO1 and GCLM), and a 2.5-fold upregulation of BiP in WT MEF cells. ML346 (0.5-25 μM) exhibits cytoprotective effects in cells after a 35 min severe heat shock, and also causes a two-fold protection from H2O2-induced apoptosis.
In Vivo: ML346 suppress the aggregation of polyQ35 in a C. elegans model, suggesting the probe has efficacy in modifying protein aggregation and associated toxicity.
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文献和实验Rapid Detection of Brucella spp. Using Loop-Mediated Isothermal Amplification (LAMP)
to humans and animals and economic losses to the livestock industry. Traditional methods for detection of Brucella spp. take 48–72 h (Kumar et al., J Commun Dis 29:131–137, 1997; Barrouin-Melo et al., Res Vet Sci 83:340–346, 2007) that do not meet the food
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- - - 100 ng/mL C22R Rspondin-1 - - - 500 ng/mL CX83 FGF-2 - - - 20 ng/mL C779 FGF-8b - - - 200 ng/mL C798 FGF-10 - - - 100 ng/mL CR11 FGF-18 - - - 10 ng/mL - SHH - - - 30 ng
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