FLI-06,313967-18-9

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FLI-06

CAS No. : 313967-18-9

MCE 国际站：FLI-06

产品活性：FLI-06是Notch信号传导的抑制剂，EC₅₀值为2.3 μM。

研究领域：Neuronal Signaling  |  Stem Cell/Wnt

作用靶点：Notch

In Vitro: FLI-06, disrupted the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A. FLI-06 inhibited general secretion at a step before exit from the endoplasmic reticulum. In FLI-06–treated cells, no APPCTF accumulates despite strongly reduced Aβ secretion, suggesting that it acts upstream of α-secretase and β-secretase cleavage. FLI-06 is a very useful chemical probe to study the inhibition of membrane traffic at pre- ER-exit site (ERES) stages without fusion of ER-Golgi.

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