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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1085822-09-8
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥588.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥500.0 |
| 规格： | 10 mg | 产品价格： | ￥800.0 |
| 规格： | 50 mg | 产品价格： | ￥2800.0 |
| 规格： | 100 mg | 产品价格： | ￥4500.0 |
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CK2/ERK8-IN-1
CAS No. : 1085822-09-8
MCE 国际站：CK2/ERK8-IN-1
产品活性：CK2/ERK8-IN-1 是一种酪蛋白激酶 2 (CK2) (Ki 为 0.25 µM) 和 ERK8 (MAPK15, ERK7) 的双重抑制剂，IC50 均为 0.50 μM。CK2/ERK8-IN-1 还与 PIM1，HIPK2 和 DYRK1A 结合，Ki 值分别为 8.65 µM，15.25 µM 和 11.9 µM。CK2/ERK8-IN-1 具有促凋亡 (pro-apoptotic) 作用。
研究领域：Cell Cycle/DNA Damage | Stem Cell/Wnt | MAPK/ERK Pathway | JAK/STAT Signaling | Protein Tyrosine Kinase/RTK | Apoptosis
作用靶点：Casein Kinase | ERK | Pim | DYRK | Apoptosis
In Vitro: CK2/ERK8-IN-1 (Compound K66; 0-50 µM; 24 hours; Jurkat cells) treatment displays cytotoxic activity in Jurkat cells.
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文献和实验三句话读懂一篇 CNS：补硒提高免疫力又添新证据；张锋开发新
., Yin, K., Zhang, X. et al. Targeting PUS7 suppresses tRNA pseudouridylation and glioblastoma tumorigenesis. Nat Cancer (2021). https://doi.org/10.1038/s43018-021-00238-02. Yu, Y., Zhang, X., Liu, F. et al. A stress-induced miR-31–CLOCK–ERK pathway
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比VEGF更强，并且这种作用呈浓度依赖性。无添加的对照里形成的管腔面积为1时，2-Cl-C.OXT-A相对值为1μM为1.36±0.40、10μM为2.44±0.89、100μM为3.78±1.09。VEGF值为1.84±0.48（各n=9、mean±SD），说明10μM 的2-Cl-C.OXT-A比VEGF有相同甚至更强的作用，而100μM的2-Cl-C.OXT-A的作用甚至是VEGF的2倍。 这种促进作用在去除了2-Cl-C.OXT-A腺嘌呤部分的碱基，（图1的C.OXT-A），腺嘌呤变成
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