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MCE 国际站:APRIL/TNFSF13 Protein, Mouse (HEK293, Fc)
APRIL 蛋白 (CD256) 是肿瘤坏死因子 (TNF) 家族中,一种能够诱导增殖的配体,调节肿瘤细胞生长,并可能参与单核/巨噬细胞介导的免疫过程。APRIL 蛋白由骨髓髓细胞及其前体产生,加快细胞成熟和外周破裂。APRIL 蛋白已被广泛用于淋巴恶性肿瘤的研究。小鼠 APRIL 蛋白是一种 II 型膜蛋白,具有细胞质结构域、疏水跨膜区和细胞外结构域。重组小鼠 APRIL/TNFSF13 蛋白 (HEK293, Fc) 由 HEK293 细胞表达 (A96-K240),带有 N 端 Fc 标签。
Synonyms: rMuAPRIL/TNFSF13, N-Fc; CD256; TALL2; APRIL; TNFSF13
Species: Mouse
Source: HEK293
研究背景:APRIL/TNFSF13 Protein is a cytokine and an independent secretory ligand belongs to TNF family. It binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. APRIL/TNFSF13 Protein plays a role in the regulation of tumor cell growth, may involve in monocyte/macrophage-mediated immunological processes.
APRIL is produced by myeloid cells and their precursors in the bone marrow. APRIL is retained by surrounding tissues and via HSPG (heparan sulfate proteoglycans) is not retained. It accumulates in large amounts in the bone marrow, leading to more rapid cell maturation and peripheral burst. As for infection response, tonsil mucosa neutrophils present within the infected tissue were the main source of APRIL, whereas keratinocytes were the primary source of APRIL in tissues showing no symptoms of infection.
APRIL acts function by binding BCMA (B cell maturation antigen) and TACI (transmembrane activator and CAML-interactor) and competes with TALL-I (also called BLyS or BAFF) for receptor binding. Soluble BCMA and TACI specifically prevent binding of APRIL and block APRIL-stimulated proliferation of primary B cells, and soluble BCMA is a dominant-negative molecule capable of inhibiting antibody production in vivo. Thus, APRIL stimulates in vitro the proliferation of primary lymphocytes, in addition to lymphoma cell lines, and promotes in vivo the accumulation of B cells in the spleen. Therefore, APRIL-TALL-I and BCMA-TACI form a two ligands-two receptors pathway involved in stimulation of B and T cell function. Moreover, APRIL is also a stimulator of tumor cell growth although TNRF death ligand-1 (TRDL-1), which induces tumor cell apoptosis.
It is a type II membrane protein with a cytoplasmic domain, a hydrophobic transmembrane region, and an extracellular domain. Mouse and human APRIL proteins are 82% identical in the COOH-terminal part of the extracellular domain, which contains the presumed receptor-binding domain. And the protein sequences of human and mouse are different with similarity of 80.91%. The APRIL protein is most often studied in the context of lymphoid malignancies.
蛋白编号:Q9D777 (A96-K240)
基因 ID:69583
产品分类:细胞因子和生长因子 | 肿瘤坏死因子超家族 | 肿瘤坏死因子配体 | APRIL 蛋白 | CD 抗原
Categories:Cytokines and Growth Factors | TNF Superfamily | TNF Superfamily Ligands | APRIL Proteins | CD Antigens
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