Unoprostone,120373-36-6

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Unoprostone

CAS No. : 120373-36-6

MCE 国际站：Unoprostone

产品活性：Unoprostone 是一种前列腺素 F2α 类似物 (PGAs)，可通过激活 BK 通道来减少氧化应激和光诱导的视网膜细胞死亡以及吞噬功能障碍。Unoprostone 可以降低眼内压，局部用于青光眼或高眼压症。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Potassium Channel

In Vitro: Pretreatment with Unoprostone (0.01, 0.1, 1 μM; 1 h before H₂O₂ treatment) protects against H₂O₂-induced cell death in a concentration-dependent manner and the effect is significant at 0.1 μM and 1 μM concentrations.
Pretreatment with Unoprostone at concentrations of 0.1 to 3 μM protects against light-induced cell death in a concentration-dependent manner; the effect is significant at the 1 and 3 μM concentrations. Unoprostone reduces the morphological change, and it significantly inhibits the low mitochondrial membrane potential and cell death induced by light irradiation.
Unoprostone has prostaglandin F_2α receptors (FP) binding affinity with a K_i of 3.86 μM.

In Vivo: Unoprostone (0.06%, 0.12%; topical instillation; 3 µl) reduces mouse intraocular pressure (IOP) in a dose-dependent manner.

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