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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
780763-95-3
- 规格：
1 mg
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CRTh2 antagonist 2
CAS No. : 780763-95-3
MCE 国际站：CRTh2 antagonist 2
产品活性：CRTh2 antagonist 2 是一种有效的选择性 CRTH2 抑制剂，对 CRTH2 的 IC50 值为 ≤10 nM，详细信息请参考专利 US20140148470A1 的化合物 Example 1。CRTh2 antagonist 2 可用于雄激素性脱发的研究。
研究领域：GPCR/G Protein
作用靶点：Prostaglandin Receptor
In Vitro: CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) protein, also known as GPR44, is a G-protein coupled receptor (GPCR) which is amongst other ligands most strongly activated by prostaglandin D2 (PGD2). PGD2 is a product of prostaglandin D2 synthase (PTGDS).
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文献和实验Characterization of Wild‐Type Excitatory Amino Acid Ion Channel Receptors
, D.E., Hutchison, A.J., Hurt, S.D., Willams, M., and Sills, M.A. 1988. Characterization of the binding of [3H]CGS‐19755: A novel N‐methyl‐D‐aspartate antagonist with nanomolar affinity in rat brain. Br. J. Pharmacol. 95:932‐938
Characterization of 5‐HT1A,B and 5‐HT2A,C Serotonin Receptor Binding
Sections Materials 100% (200 proof), 95%, 70%, and 50% ethanol, low grade
Practical Aspects of Radioligand Binding
Figure 1.3.3 Competition between a radiolabeled antagonist and an unlabeled agonist for muscarinic receptors on N1E‐115 cells. [3 H]Quinuclidinyl benzilate ([3 H]QNB; 0.2 nM) was incubated with 200,000 intact cells/tube and various concentrations
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