PROTAC FKBP Degrader-3,2079056

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PROTAC FKBP Degrader-3

CAS No. : 2079056-43-0

MCE 国际站：PROTAC FKBP Degrader-3

产品活性：PROTAC FKBP Degrader-3 是一种包含 FKBP 配体结合基团，linker 和 von Hippel-Lindau 结合基团的 PROTAC。PROTAC FKBP Degrader-3 是一种有效的 FKBP 降解剂。

研究领域：PROTAC  |  Autophagy  |  Apoptosis  |  Immunology/Inflammation

作用靶点：PROTACs  |  FKBP

In Vitro: PROTAC treatment time courses demonstrated a notable increase in polyubiquitination of EGFP-FKBP in response to treatment with 250 nM of PROTAC FKBP Degrader-3 (compound 10) for VHL within the first hour. Upon recruiting endogenous VHL via PROTAC FKBP Degrader-3 (compound 10), only one EGFP background lysine (Lys158) is found to be ubiquitylated.

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