BAY1082439,1375469-38-7

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BAY1082439

CAS No. : 1375469-38-7

MCE 国际站：BAY1082439

产品活性：BAY1082439 是一种具有口服活性的，选择性 PI3Kα/β/δ 抑制剂。BAY1082439 也能抑制 PIK3CA 的突变形式，BAY1082439 对抑制 Pten 丢失的前列腺癌的生长有很强的作用。

研究领域：PI3K/Akt/mTOR  |  Apoptosis

作用靶点：PI3K  |  Apoptosis

In Vitro: BAY1082439 is a highly selective PI3Kα/α-balanced inhibitor. BAY1082439 has an IC₅₀ ratio of 1:3 in biochemical assays of PI3Kα (4.9 nM) vs. PI3Kα (15.0 nM), and >1000-fold selectivity against mTOR kinase.
BAY1082439 (0.1-1 μM; 72 hours) is more effective than PI3Kα- and/or PI3Kβ-selective inhibitors in blocking PTEN-null prostate cancer cells.

In Vivo: BAY1082439 (75 mg/kg; p.o.; daily for 4 weeks) is effective in preventing Pten-null prostate cancer progression.

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