- 询价
- 近岸蛋白(Novoprotein)
- DRA49
- 2025年12月02日
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 英文名：
Recombinant 2019-nCoV S-trimer Protein (C-6His)
- 保存条件：
Reconstituted protein solution should be stored at ≤ -20°C.
- 规格：
1mg
Recombinant 2019-nCoV S-trimer Protein (C-6His)
Catalog #: DRA49 Derived From: Human Cells
Description:
Recombinant 2019-nCoV S-trimer Protein is produced by our Mammalian expression system with a 6His tag at the C-terminus.
Accession: QHD43416.1
Names(Known as): 2019-nCov S protein; 2019-nCoV Spike glycoprotein; 2019-nCoV S glycoprotein
Quality Control:
Mol Mass: 136.6kDa AP Mol Mass: 170-220kDa, reducing conditions
Purity: Greater than 95% as determined by reducing SDS-PAGE.
Formulation:
Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Shipping:
The product is shipped on dry ice pack.
Upon receipt, store it immediately at the temperature listed below.
Storage:
Reconstituted protein solution should be stored at ≤ -20°C.
Purification:
Affinity purification chromatography.
Immunoreactivity:
N.A.
Application:
Immunogen, calibrator or standard.
Background:
Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY
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- 作者
- 内容
- 询问日期
文献和实验Protein S (PS) is a vitamin K-dependent plasma glycoprotein. Around 60–70% of PS in plasma is noncovalently bound to C4-binding protein (C4BP). Free PS functions as a cofactor that enhances the activity of activated protein C (APC
Analysis of the Protein S Gene in Protein S Deficiency
Protein S (PS) is a 71-kDa vitamin K-dependent glycoprotein first identified in human plasma by DiScipio and colleagues in 1977 (1 ), a year after the discovery of the anticoagulant protein C (PC) (2 ,3 ). A few years later, Walker
谢灵顿，C.S. 谢灵顿，C.S. （Charles Scott Sherrington1857～1952） 英国神经生理学家。1857年11月27日生于英国伊斯灵顿，1952年3月4日卒于英国伊斯特本。1876年起在伦敦圣托马斯医院学习，1880年前往剑桥，成为凯厄斯学院的成员，1885年取得医学士学位，翌年获医师资格，然后回到圣托马斯医院任讲师，1891年任伦敦大学兽医院布朗研究所的教授和所长，1895～1913年任利物浦大学教授，1913～1935年任牛津
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