- 询价
- 近岸蛋白(Novoprotein)
- DRA38
- 2025年11月27日
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 保存条件：
Reconstituted protein solution should be stored at ≤ -20°C.
- 英文名：
Recombinant 2019-nCoV S Protein RBD-SD1 (C-mFC)
- 规格：
50μg/500μg/1mg
Recombinant 2019-nCoV S Protein RBD-SD1 (C-mFC)
Catalog #: DRA38 Derived From: Human Cells
Description:
Recombinant 2019-nCoV S protein RBD Protein is produced by our Mammalian expression system and the target gene encoding Arg319-Pro589 is expressed with a mFC tag at the C-terminus.
Accession: QHD43416.1
Names(Known as): 2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein
Quality Control:
Mol Mass: 57kDa AP Mol Mass: 60-80kDa, reducing conditions
Purity: Greater than 95% as determined by reducing SDS-PAGE.
Bioactivity:
Immobilized Human ACE-2-Fc(Cat#C05Y) at 2μg/ml (100 μl/well) can bind 2019-nCoV S Protein RBD-SD1-mFc(Cat#DRA38). The ED50 of 2019-nCoV S Protein RBD-SD1-mFc(Cat#DRA38) is 15.5 ng/ml.
Formulation:
Supplied as a 0.2 μM filtered solution of PBS, pH 7.4
Shipping:
The product is shipped on dry ice pack.
Upon receipt, store it immediately at the temperature listed below.
Storage:
Reconstituted protein solution should be stored at ≤ -20°C.
Purification:
Affinity purification chromatography.
Immunoreactivity:
N.A.
Application:
Immunogen, calibrator or standard.
Background:
Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY
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- 内容
- 询问日期
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Analysis of the Protein S Gene in Protein S Deficiency
Protein S (PS) is a 71-kDa vitamin K-dependent glycoprotein first identified in human plasma by DiScipio and colleagues in 1977 (1 ), a year after the discovery of the anticoagulant protein C (PC) (2 ,3 ). A few years later, Walker
Combined 3C-ChIP-Cloning (6C) Assay: A Tool to Unravel Protein-Mediated Genome Architecture
between chromatin elements without specifically identifying the protein components that mediate such interactions. Here we describe a detailed protocol for C ombined 3C -C hIP-C loning (6C) technology, which combines multiple techniques to identify the proteins
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