(R)-BMS-816336,1009583-83-8

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(R)-BMS-816336

CAS No. : 1009583-83-8

MCE 国际站：(R)-BMS-816336

产品活性：(R)-BMS-816336 (Compound 6n-1) 是一种有效的口服活性的人，小鼠和食蟹猴 11β-羟类固醇脱氢酶 1 型 (11β-HSD1) 抑制剂，其 IC₅₀ 分别为 14.5 nM，50.3 nM 和 16 nM。

研究领域：Metabolic Enzyme/Protease

作用靶点：11β-HSD

In Vivo: During the in vivo studies of BMS-816336 (Compound 6n-2) in animals, its enantiomer (R)-BMS-816336 (Compound 6n-1) in the plasma samples, together with trace amount of Ketone A are detected. The interconversion of BMS-816336 and (R)-BMS-816336 take place via the intermediate Ketone A through physiological oxidation and reduction process. In vivo studies in rat, dog, and cynomolgus monkey, the plasma ratios of (R)-BMS-816336/BMS-816336 decrease in the order: dog ≫ rat >cynomolgus monkey.

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