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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
SMT C1100; BMN 195; VOX-C1100
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥880.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥800.0 |
| 规格： | 10 mg | 产品价格： | ￥1280.0 |
| 规格： | 25 mg | 产品价格： | ￥2560.0 |
| 规格： | 50 mg | 产品价格： | ￥4080.0 |
| 规格： | 100 mg | 产品价格： | ￥6560.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Ezutromid
CAS No. : 945531-77-1
MCE 国际站：Ezutromid
产品活性：Ezutromid (SMT C1100) 是一种首创的，具有口服活性的苯并恶唑 utrophin 调节剂， EC50 为 0.91 μM。Ezutromid 可用于 Duchenne 型肌营养不良症 (DMD) 的研究。Ezutromid 抑制人肝微粒体 CYP1A2 酶活性，IC50 为 5.4 μM。
研究领域：Metabolic Enzyme/Protease
作用靶点：Cytochrome P450
In Vitro: Ezutromid induces increased levels of utrophin RNA in human muscle cells. Treatment of human DMD cells with Ezutromid lead to a 2-fold increase in utrophin protein levels at an optimal concentration of 0.3 uM after 3 days of treatment. Ezutromid was safe and well tolerated with plasma concentrations achieved suf cient to cause a 50% increase in concentrations of utrophin in cells. Ezutromid led to a 30% increase in Utrn mRNA level and resulted in a 2.0-fold increase in UTRN protein level.
In Vivo: Note: You can dissolve the products in phosphate buffered saline (PBS), 0.1% Tween-20, 5% DMSO)
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