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4°C, protect from light
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货期：1-2天
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- CAS号：
127-22-0
- 规格：
1 mg/5 mg/10 mg
| 规格： | 1 mg | 产品价格： | ￥770.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥2000.0 |
| 规格： | 10 mg | 产品价格： | ￥3200.0 |
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Taraxerol
CAS No. : 127-22-0
MCE 国际站：Taraxerol
产品活性：Taraxerol 是从蒲公英中分离出来的，具有抗炎和抗癌作用。Taraxerol 通过抑制 NF-κB 信号通路来减轻急性炎症。Taraxerol 诱导细胞凋亡 (apoptosis)。
研究领域：Apoptosis | NF-κB
作用靶点：Apoptosis | NF-κB
In Vitro: Taraxerol (0-100 μM; 24 or 48 hours)significantly reduces cell viability to 95%? (20 μM), 89.8%? (40 μM), 82.6 %? (60 μM), 72.9 % (80 μM), and 63.6%? (100 μM).And this compound has cell viability of 90.7% at a concentration of 20 μM and 53.6%? at the 100 μM concentration at 48 hours in Hela cells.
?Taraxerol (80 μM; 24 or 48 hours) induces Hela cells apoptosis and cell death in a dose-dependent manner.Taraxerol can induce a significant apoptosis of cells by annexin V/ PI double staining,? significant increase in both the early (24.2%) and late (16.2%) stages of apoptotic cells compared with the control group at the early (6.5%) and late (0.5%) stages.
In Vivo: Taraxerol (5 and 10mg/kg; i.p.)? attenuates carrageenan induced paw edema. The effect of?taraxerol?at the dose of 5mg/kg is found to be significant (p<0.05) only after 4h of carrageenan treatment.
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文献和实验0.0005 1 1.000 3.078 6.314 12.706 31.821 63.657 127.321 318.309 636.619 2 0.816 1.886 2.920 4.303 6.965 9.925 14.089 22.327 31.599 3 0.765 1.638 2.353 3.182 4.541 5.841 7.453 10.215 12.924 4 0.741 1.533 2.132 2.776 3.747 4.604
参考文献： ［1］Donohoe GG et al. Clin Chem，1999，45(1)：143～146 ［2］Grossman PD. Nucleic Acids Res，1994，22：4527～4534 ［3］Barta C et al. J Chromatogr A，1998，817(1－2)： 281～286 ［4］Mitchell CE et al. Anal Biochem，1995，224：148～153 ［5］Fasco MJ
各位啦！ MKKTLLLSLSLSLSFLLHAEDDGFYTSVGYQIGEAAQMVKNTKGIQELSDNYEKLNNLLNNYSTLNTLIKLSADPSAINDARDNLGSSSRNLLDVKTNSPAYQAVLLALNAAVGLWQVTSYAFTACGPGSNENANGGIQTFNNVPGQDTTTITCNSYYEPGHGGPISTANYAKINQAYQIIQKALTANGANGDGVPVLSNTTTKLDFTINGDKRTGGKPNTPEKFPWSDGKYIHTQWINTIVTPTETNINTENNAQELLKQASIIITTLNEACPNFQNGGRSYWQGISGNGTMCGMFKNEISAIQGMIANAQEAVAQSKIVSENAQNQNNLDTGKPFNPYTDASFAQSMLKNAQAQAEILNQAEQVVKNFEKIPTAFVSDSLGVCYEVQGGERRGTNPGQVTSNTWGAGCAYVKQTITNLDNSIAHFGTQEQQIQQAENIADTLVNFKSRYSELGNTYNSITTALSKVPNAQSLQNVVSKKNNPYSPQGIETNYYLNQNSYNQIQTINQELGRNPFRKVGIVNSQTNNGAMNGIGIQVGYKQFFGQKRKWGARYYGFFDYNHAFIKSSFFNSASDVWTYGFGADALYNFINDKATNFLGKNNKLSVGLFGGIALAGTSWLNSEYVNLATVNNVYNAKMNVANFQFLFNMGVRMNLARSKKKGSDHAAQHGIELGLKIPTINTNYYSFMGAELKYRRLYSVYLNYVFAY There are 26 antigenic determinants in your sequence: n Start Sequence End Position Position 1 4 TLLLSLSLSLSFLLH 18 2 24 FYTSVGY 30 3 64 TLNTLIKLSAD 74 4 89 SRNLLDV 95 5 99 SPAYQAVLLALNAAVGLWQVTSYAFTACG 127 6 173 KINQAYQIIQKA 184 7 193
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