A-317567,371217-32-2

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A-317567

CAS No. : 371217-32-2

MCE 国际站：A-317567

产品活性：A-317567 是一种有效的酸敏感离子通道 3 (ASIC-3) 抑制剂，IC₅₀ 为 1.025 μM。A-317567 具有抗抑郁和缓解疼痛作用。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Sodium Channel

In Vitro: In acutely dissociated adult rat dorsal root ganglion (DRG) neurons, A-317567 produces concentration-dependent inhibition of all pH 4.5-evoked ASIC currents with an IC₅₀ ranging between 2 and 30 μM. A-317567 equipotently blocks the sustained phase of ASIC3-like current, a biphasic current akin to cloned ASIC3, which is predominant in DRG.

In Vivo: A-317567 (1-100 μmol/kg; i.p; once) is fully analgesic effects in the CFA model (ED₅₀ of 17 μmol/kg). There is no significant effect of A-317567 on the withdrawal latency of the contralateral paw under these conditions.

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