Abeprazan,1902954-87-3

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Abeprazan hydrochloride

CAS No. : 1902954-87-3

MCE 国际站：Abeprazan hydrochloride

产品活性：Abeprazan (DWP14012) hydrochloride 是一种钾竞争性酸 (potassium-competitive acid) 阻滞剂。Abeprazan hydrochloride 通过可逆的钾竞争性离子结合抑制 H⁺，K⁺- ATPase，而无需酸激活。Abeprazan hydrochloride 是一种潜在的质子泵抑制剂，用于研究与酸相关的疾病。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Proton Pump

In Vitro: The mechanism of action of Abeprazan hydrochloride is reversibly binding to H⁺, K⁺‐ATPase, and, unlike that of PPIs, does not require acidic environment for drug activation.

In Vivo: Abeprazan hydrochloride (DWP14012 hydrochloride) inhibits acid secretion in a dose-dependent manner and the inhibition of gastric acid secretion is equal to or greater than that of vonoprazan, a previously approved P-CAB, in various in vivo studies using pylorus-ligated rats, lumen-perfused rat models and heidenhain pouch dog models.

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