- ￥659 - 9500
- MedChemExpress(MCE)
- 美国
- HY-100080
- 2025年07月14日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1266212-81-0
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1595.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥659.0 |
| 规格： | 5 mg | 产品价格： | ￥1450.0 |
| 规格： | 10 mg | 产品价格： | ￥2550.0 |
| 规格： | 25 mg | 产品价格： | ￥5500.0 |
| 规格： | 50 mg | 产品价格： | ￥9500.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
A-887826
CAS No. : 1266212-81-0
MCE 国际站：A-887826
产品活性：A-887826 是一种高效、选择性的，口服有效的，电压依赖性的 Na(v)1.8 钠通道阻滞剂，其 IC50 值为 11 nM。在体内，A-88782 6可减轻神经性触觉痛。
研究领域：Membrane Transporter/Ion Channel
作用靶点：Sodium Channel
In Vitro: A-887826 is approximately 3 fold less potent to block Na(v)1.2, approximately 10 fold less potent to block tetrodotoxin-sensitive sodium (TTX-S Na(+)) currents and is >30 fold less potent to block Na(v)1.5 channels.
A-887826 potently blocks tetrodotoxin-resistant sodium (TTX-R Na(+)) currents (IC50=8 nM) from small diameter rat dorsal root ganglion (DRG) neurons in a voltage-dependent fashion.
A-887826 effectively suppresses evoked action potential firing when DRG neurons are held at depolarized potentials and reversibly suppresses spontaneous firing in small diameter DRG neurons from complete Freund's adjuvant inflamed rats.
A-887826 (100 nM) shifts the mid-point of voltage-dependent inactivation of TTX-R currents by approximately 4mV without affecting voltage-dependent activation and do not exhibit frequency-dependent inhibition.
In Vivo: A-887826 (3-30 mg/kg; p.o.; 1 hour pre-treatment) significantly attenuates tactile allodynia in a rat neuropathic pain model.
相关产品：Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Neuroprotective Compound Library | Sodium Channel Blocker Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Ion Channel Compound Library | Amiloride hydrochloride | Halofuginone | Carbamazepine | Riluzole | 20(S)-Ginsenoside Rg3 | TPC2-A1-P | Lidocaine | Amitriptyline hydrochloride | Veratridine | 5-(N,N-Hexamethylene)-amiloride | Triamterene | Fluphenazine dihydrochloride | Lamotrigine | Flunarizine dihydrochloride | QX-314 chloride | Phenytoin | A-803467 | Ranolazine | Benzamil hydrochloride | Vinpocetine | Dronedarone | GS967 | Metergoline | PF 05089771 | Primidone | Propafenone hydrochloride
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
