重组猴IL-13北京供应商

特别提示：包括重组猴IL-13在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组猴IL-13
英文名称：Recombinant Rhesus Macaque Interleukin-13
产品货号：GS4681
产品规格：2μg

分子量：Approximately12.6kDa,a single non-glycosylated polypeptide chain containing 114 amino acids.
储存条件：冷冻（-20℃）

概述

Interleukin-13(IL-13)is expressed by the IL13 gene and secreted by many cell types,especially T helper type 2(Th2)cells.The high solution from of IL-13 reported to be a monomer with two internal disulfide bonds that contribute to a bundled four α-helix configuration.Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites.IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1beta,TNF-alpha,IL-6 and IL-8.IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE.Mature rhesus IL-13 shares 94%,58%,and 60%amino acid sequence identity with human,mouse,and rat IL-13,respectively.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞98%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 5ng/ml,corresponding to a specific activity of>2.0×105 IU/mg.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4,3%trehalose.
内毒素	Less than 1 EU/μg of rRhIL-13 as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/ml.Stock solutions should be apportioned into working aliquots and stored at ≤ -20?C.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	SPSPVPRSTA LKELIEELVN ITQNQKAPLC NGSMVWSINL TAGVYCAALE SLINVSGCSA IEKTQRMLNG FCPHKVSAGQ FSSLRVRDTK IEVAQFVKDL LVHLKKLFRE GRFN

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