Human IFN-gamma

Recombinant Human IFN-γ

产品详情

产品编号：300-02
产品描述：

IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells.  IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins.  This promotes the presentation of antigen to T-helper (CD4+) cells.  IFN-γ signaling in antigen-presenting cells, and antigen-recognizing B and T lymphocytes, regulates the antigen-specific phases of the immune response.  Additionally, IFN-γ stimulates a number of lymphoid cell functions, including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils.  Human IFN-γ is species-specific and is biologically active only in human and primate cells.  Recombinant Human IFN-γ is a 16.8 kDa protein containing 144 amino acid residues.

Source:E.coli

 

Synonyms:Immune Interferon, type II interferon, T cell interferon, MAF

 

AA Sequence:MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ

 

Purity:≥ 98% by SDS-PAGE gel and HPLC analyses.

 

Biological Activity:Assay #1: Determined by its ability to induce STAT1/STAT2 activation in Human COLO 205 ISRE LUC reporter cells.

Assay #2: The ED₅₀ determined by a cytotoxicity assay using HT-29 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 10⁷ units/mg.

 

Calculated Molecular Weight:16.8 kDa

 

Accession Number:P01579.1

 

Gene ID:3458

 

crossreactivity:
Bacteria, Fish + Virus, Human , Human + Bacteria, Human + Hamster, Human + Mouse, Human + Virus, Mandarin Fish, Monkey, Mouse, N/A, Pig, Rabbit, Rat