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文献和实验Mutational Analysis of the Human Protein C Gene
The single gene for protein C is located at position q13–q14 on chromosome 2 (1 ). Two groups have described human genomic clones of protein C isolated from phage l charon libraries using cDNA for human protein C as hybridization probes
Production of Human Monoclonal Antibodies to Hepatitis C Virus and Their Characterization
Human monoclonal antibodies (hMAb) provide novel ways to probe the B-cell repertoire in health and disease. However, the development of hMAb technology has met with several difficulties owing to the instability of the cell lines, the low
Inducible microRNA-Mediated Knockdown of the Endogenous Human Lamin A/C Gene
inactivation both in vitro and in vivo. Here, the generation of a conditional RNAi cell line for microRNA (miRNA)-mediated downregulation of the endogenous lamin A/C gene is described. A tet-responsive transcription unit, encoding a designed miRNA against human
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