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文献和实验Nitric oxide (NO) is an important bio-regulatory molecule in the nervous, immune and cardiovascular systems. The physiological involvement of NO in neuronal transmission, control of vascular tone, and immune response-induced cytostasis
Nitric Oxide Synthase Inhibitors
In 1990, several studies reported that an enhanced formation of endogenous nitric oxide (NO) contributes to the hypotension caused by endotoxin and tumor-necrosis factor-α (TNFα) (1 –3 ). In addition, it became apparent
Purification of the Inducible Nitric Oxide Synthase
Regulation of the inducible nitiric oxide synthase (iNOS) isozyme is distinct from the constitutively expressed endothelial (e) and neuronal (n) NOS isozymes in that it occurs at the level of gene expression and not by Ca+2 /calmodulin (CaM
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