HA130 is a selective ATX (autotaxin) inhibitor with IC50 of 28nM.
信号通路
Metabolism; Proteases
靶点
ATX
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IC50
28nM
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体外研究
HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3μM completely ablates the activity of ATX on TK1 uropod formation.
体内研究
HA130 instantaneously lowers plasma levels of LPA in mice after intravenous administration. HA130 is an inhibitor of the enzymatic activity of ATX, slows T cell migration across lymph node HEVs. HA130 decreased the "outside HEVs/inside HEVs" ratio by 3-4-fold, compared to vehicle-treated animals vehicle (p<0.01 for both PLNs and mlNs).
临床实验
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特征
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相关实验数据(此数据来自于公开文献,信裕生物并不保证其有效性):
酶活性检测实验
方法
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细胞实验
细胞系
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浓度
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处理时间
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方法
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动物实验
动物模型
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配制
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剂量
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给药方式
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参考文献: 1. Zhang Y, et al. J Immunol. 2012 Oct 15, 189(8), 3914-3924.
2. Bai Z, et al. J Immunol. 2013 Mar 1, 190(5), 2036-2048.
包装清单: