R&D Systems货号AF3628现货Human/Mou
se/Rat CD31/PECAM-1 Antibody上海睿安生物R&D Systems-Tocris官方正式授权代理19121878899- ￥5661.01
- R&D Systems
- AF3628
- made in USA
- 2026年03月16日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
10⁺支
- 英文名：
Human/Mouse/Rat CD31/PECAM-1 Antibody
- 保质期：
1年
- 供应商：
上海睿安生物19121878899
- 保存条件：
-20°C
- 规格：
100μl/支
R&D Systems货号AF3628现货Human/Mouse/Rat CD31/PECAM-1 Antibody上海睿安生物19121878899
Human/Mouse/Rat CD31/PECAM-1 Antibody Summary
Glu18-Lys590
Accession # Q08481
*Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Background: CD31/PECAM-1
PECAM-1 (Platelet-Endothelial Cell Adhesion Molecule-1), also known as CD31, is a 130 kDa type I transmembrane glycoprotein adhesion molecule in the immunoglobulin superfamily (1, 2). Expression is restricted to cells involved in circulation, especially endothelial cells, platelets, monocytes, neutrophils and lymphocyte subsets. PECAM-1 is concentrated at cell-cell junctions and is required for Transendothelial Migration (TEM) (1-3). The Extracellular Domain (ECD) of PECAM-1 has ten potential N-linked glycosylation sites and six C2-type Ig-like domains, the first of which is critical for adhesion and extravasation (3, 4). The cytoplasmic domain contains Immunoregulatory Tyrosine-based Inhibitory and Switch Motifs (ITIM, ITSM) that mediate both inhibition and activation via phosphotyrosine-mediated engagement of SH2-containing signaling molecules (1, 5). Metalloproteinase-mediated ectodomain shedding occurs during apoptosis (6) but increased serum PECAM-1 ectodomain in HIV and active multiple sclerosis occurs independent of apoptosis (7, 8). In humans, expression of six isoforms with exon deletions in the cytoplasmic domain is tissue- and stage-specific, but full-length PECAM-1 is predominant. A form lacking the ITSM predominates in mouse (9). Mouse PECAM-1 ECD shows 77%, 63%, 63%, 63%, and 61% amino acid (aa) identity with rat, human, canine, porcine, and bovine PECAM-1, respectively. PECAM-1 participates with other adhesion molecules in some functions, but is the critical molecule for TEM. Homotypic PECAM-1 adhesion in trans, combined with cycling of PECAM-1 to and from surface-connected endothelial cell vesicles, leads leukocytes across endothelial tight junctions (3, 10). Homotypic adhesion and signaling functions also strongly suppress mitochondria-dependent apoptosis (11). In platelets, PECAM-1 is necessary for limiting thrombus formation (12) and promoting integrin-mediated clot retraction and platelet spreading (13), but mechanisms for these phenomena are unclear. PECAM-/- mice are deficient in chemokine-mediated chemotaxis (14).
Citations for Human/Mouse/Rat CD31/PECAM-1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
546 Citations: Showing 1 - 10
Filter your results:
Filter by:
- Engrailed 1 coordinates cytoskeletal reorganization to induce myofibroblast differentiation
Authors: Gyorfi Ah, Matei Ae, Fuchs M Et Al.
The Journal of experimental medicine - TRAF3IP2 mediates high glucose-induced endothelin-1 production as well as endothelin-1-induced inflammation in endothelial cells.
Authors: Padilla J, Carpenter A, Das ND et al.
Am. J. Physiol. Heart Circ. Physiol. - Semiautomated pipeline for quantitative analysis of heart histopathology
Authors: Droste, P;Wong, DWL;Hohl, M;von Stillfried, S;Klinkhammer, BM;Boor, P;
Journal of translational medicine - Mono- and multi-nucleated ventricular cardiomyocytes constitute a transcriptionally homogenous cell population
Authors: Yekelchyk M, Guenther S, Preussner J, Braun T
Basic Res. Cardiol. - CD31 signaling promotes the detachment at the uropod of extravasating neutrophils allowing their migration to sites of inflammation
Authors: Andreata, F;Clément, M;Benson, RA;Hadchouel, J;Procopio, E;Even, G;Vorbe, J;Benadda, S;Ollivier, V;Ho-Tin-Noe, B;Le Borgne, M;Maffia, P;Nicoletti, A;Caligiuri, G;
eLife - FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway.
Authors: Li J, Shi S, et al.
Cell Death Dis - Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic
Authors: Logan T, Simon MJ, Rana A Et al.
Cell - Endothelial AHR activity prevents lung barrier disruption in viral infection
Authors: Major, J;Crotta, S;Finsterbusch, K;Chakravarty, P;Shah, K;Frederico, B;D'Antuono, R;Green, M;Meader, L;Suarez-Bonnet, A;Priestnall, S;Stockinger, B;Wack, A;
Nature - THBS4/integrin alpha 2 axis mediates BM-MSCs to promote angiogenesis in gastric cancer associated with chronic Helicobacter pylori infection
Authors: LingNan He, WeiJun Wang, HuiYing Shi, Chen Jiang, HaiLing Yao, YuRui Zhang et al.
Aging (Albany NY) - Exosomes released from educated mesenchymal stem cells accelerate cutaneous wound healing via promoting angiogenesis
Authors: Xinyu Qiu, Jin Liu, Chenxi Zheng, Yuting Su, Lili Bao, Bin Zhu et al.
Cell Proliferation
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文献和实验R&D Systems货号AF3628现货Human/Mouse/Rat CD31/PECAM-1 Antibody上海睿安生物19121878899
Human/Mouse/Rat CD31/PECAM-1 Antibody Summary
Glu18-Lys590
Accession # Q08481
*Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Background: CD31/PECAM-1
PECAM-1 (Platelet-Endothelial Cell Adhesion Molecule-1), also known as CD31, is a 130 kDa type I transmembrane glycoprotein adhesion molecule in the immunoglobulin superfamily (1, 2). Expression is restricted to cells involved in circulation, especially endothelial cells, platelets, monocytes, neutrophils and lymphocyte subsets. PECAM-1 is concentrated at cell-cell junctions and is required for Transendothelial Migration (TEM) (1-3). The Extracellular Domain (ECD) of PECAM-1 has ten potential N-linked glycosylation sites and six C2-type Ig-like domains, the first of which is critical for adhesion and extravasation (3, 4). The cytoplasmic domain contains Immunoregulatory Tyrosine-based Inhibitory and Switch Motifs (ITIM, ITSM) that mediate both inhibition and activation via phosphotyrosine-mediated engagement of SH2-containing signaling molecules (1, 5). Metalloproteinase-mediated ectodomain shedding occurs during apoptosis (6) but increased serum PECAM-1 ectodomain in HIV and active multiple sclerosis occurs independent of apoptosis (7, 8). In humans, expression of six isoforms with exon deletions in the cytoplasmic domain is tissue- and stage-specific, but full-length PECAM-1 is predominant. A form lacking the ITSM predominates in mouse (9). Mouse PECAM-1 ECD shows 77%, 63%, 63%, 63%, and 61% amino acid (aa) identity with rat, human, canine, porcine, and bovine PECAM-1, respectively. PECAM-1 participates with other adhesion molecules in some functions, but is the critical molecule for TEM. Homotypic PECAM-1 adhesion in trans, combined with cycling of PECAM-1 to and from surface-connected endothelial cell vesicles, leads leukocytes across endothelial tight junctions (3, 10). Homotypic adhesion and signaling functions also strongly suppress mitochondria-dependent apoptosis (11). In platelets, PECAM-1 is necessary for limiting thrombus formation (12) and promoting integrin-mediated clot retraction and platelet spreading (13), but mechanisms for these phenomena are unclear. PECAM-/- mice are deficient in chemokine-mediated chemotaxis (14).
Citations for Human/Mouse/Rat CD31/PECAM-1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
546 Citations: Showing 1 - 10
Filter your results:
Filter by:
- Engrailed 1 coordinates cytoskeletal reorganization to induce myofibroblast differentiation
Authors: Gyorfi Ah, Matei Ae, Fuchs M Et Al.
The Journal of experimental medicine - TRAF3IP2 mediates high glucose-induced endothelin-1 production as well as endothelin-1-induced inflammation in endothelial cells.
Authors: Padilla J, Carpenter A, Das ND et al.
Am. J. Physiol. Heart Circ. Physiol. - Semiautomated pipeline for quantitative analysis of heart histopathology
Authors: Droste, P;Wong, DWL;Hohl, M;von Stillfried, S;Klinkhammer, BM;Boor, P;
Journal of translational medicine - Mono- and multi-nucleated ventricular cardiomyocytes constitute a transcriptionally homogenous cell population
Authors: Yekelchyk M, Guenther S, Preussner J, Braun T
Basic Res. Cardiol. - CD31 signaling promotes the detachment at the uropod of extravasating neutrophils allowing their migration to sites of inflammation
Authors: Andreata, F;Clément, M;Benson, RA;Hadchouel, J;Procopio, E;Even, G;Vorbe, J;Benadda, S;Ollivier, V;Ho-Tin-Noe, B;Le Borgne, M;Maffia, P;Nicoletti, A;Caligiuri, G;
eLife - FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway.
Authors: Li J, Shi S, et al.
Cell Death Dis - Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic
Authors: Logan T, Simon MJ, Rana A Et al.
Cell - Endothelial AHR activity prevents lung barrier disruption in viral infection
Authors: Major, J;Crotta, S;Finsterbusch, K;Chakravarty, P;Shah, K;Frederico, B;D'Antuono, R;Green, M;Meader, L;Suarez-Bonnet, A;Priestnall, S;Stockinger, B;Wack, A;
Nature - THBS4/integrin alpha 2 axis mediates BM-MSCs to promote angiogenesis in gastric cancer associated with chronic Helicobacter pylori infection
Authors: LingNan He, WeiJun Wang, HuiYing Shi, Chen Jiang, HaiLing Yao, YuRui Zhang et al.
Aging (Albany NY) - Exosomes released from educated mesenchymal stem cells accelerate cutaneous wound healing via promoting angiogenesis
Authors: Xinyu Qiu, Jin Liu, Chenxi Zheng, Yuting Su, Lili Bao, Bin Zhu et al.
Cell Proliferation
祝贺〖雅裕睿安〗成为Signalway Antibody(SAB)独家
Secondary antibody unconjugated； 货号3022，产品描述：Goat anti-Human IgG Secondary antibody HRP conjugated； 货号3031，产品描述：Goat anti-Mouse IgG Secondary antibody unconjugated； 货号3032，产品描述：Goat anti-Mouse IgG Secondary
secondary antibody review -- data from 99 publications
cytometry used as a control to detect cell responses targeted antigen 7 Alexa Fluor 488 7 Cy3 8 goat IgG Alexa Fluor 488 1:2000 detect antibody binding in human embryonic kidney 293T cells Invitrogen 9 donkey
NRK 肾细胞L-6TG 肌母细胞 3.仓鼠类BHK 幼仓鼠肾V79 中国仓鼠肺细胞CHL 中国仓鼠肺细胞CHO 中国仓鼠卵巢细胞R1610 中国仓鼠体细胞*CHO/dhFr- 二氢叶酸还原酶缺陷型CHO4．人类 2BS 胚肺 XJH B淋巴细胞 HLF 胚肺 L-02 肝细胞 WI-38 胚肺 Chang Liver 张氏肝 SL-7 胚肺 QSG-7701 肝细胞 H.A. 羊膜 293 Ad5DNA转化的胚肾 WISH 羊膜
