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- 2025年10月16日
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| 规格： | 100ug | 产品价格： | ￥1880.0 |
|---|---|---|---|
| 规格： | 20ug | 产品价格： | ￥580.0 |
| 规格： | 500ug | 产品价格： | ￥5680.0 |
| 产品编号 | bs-41114P |
| 英文名称 | Recombinant human Creatine Kinase MB protein, N-His |
| 中文名称 | 重组人肌酸激酶同工酶CKMB蛋白 |
| 英文别名 | CK-MB; B-CK; brain creatine kinase; CKBB; CKMB; CKMM; creatine kinase B; creatine kinase brain; creatine kinase M; Creatine kinase MB; Creatine Kinase MB type; creatine kinase muscle; M-CK; creatine kinase-M/B; KCRB_HUMAN; muscle creatine kinase; Recombinant human Creatine Kinase MB protein, His |
| 性状 | Liquid |
| 纯化方法 | AC |
| 理论分子量 | 90.9 |
| 浓度 | ＞0.5 mg/ml |
| 储存液 | PBS (pH7.4) with 1mM EDTA and 1mM DTT. |
| 研究领域 | Cancer > Cancer Metabolism > Metabolic signaling pathway > Integration of energy metabolism Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Energy Metabolism Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Integration of energy Metabolism > Types of disease > Cancer Neuroscience > Neurotransmission > Intracellular Signaling > Kinases Signal Transduction > Metabolism > Energy Metabolism |
| 亚基 | Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain. |
| 亚细胞定位 | Cytoplasmic and Mitochondrial |
| 相似性 | Belongs to the ATP:guanido phosphotransferase family. Contains 1 phosphagen kinase C-terminal domain. Contains 1 phosphagen kinase N-terminal domain. |
| 功能 | Creatine Kinase MB consists of a dimer of nonidentical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain. Creatine Kinase MB reversibly catalyses the transfer of phosphate between ATP and various phosphogens. The creatine kinase isoenzymes play a central role in energy transduction in tissues with large fluctuating energy demands such as skeletal muscle, heart, brain and spermatozoa. |
| 保存条件 | Stored at 2-8℃ for one year. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The Creatine Kinase MB（CK-MB） isoenzyme is predominantly found in the myocardium (heart muscle). Following a heart attack (myocardial infarction), damaged cells release CK-MB into the blood; these elevated CK levels can be seen 4-8 hours post-infarction and remain elevated for a few days. This makes creatine kinase a useful biomarker for assessing damage to CK-rich tissues, as in cases of rhabdomyolysis (severe muscle breakdown), acute kidney injury, and heart attack. |
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文献和实验[IF={{ 1.3 }}] {Tao Zhong. et al. Electrochemical immunosensor based on gold nanoparticles for the detection of creatine kinase as a cardiac marker. INT J ELECTROCHEM SC. 2024 Nov;19:100821} {} {}
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Medium-Throughput Production of Recombinant Human Proteins: Protein Production in Insect Cells
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High Throughput Production of Recombinant Human Proteins for Crystallography
This chapter presents in detail the process used in high throughput bacterial production of recombinant human proteins for crystal structure determination. The core principles are: (1 ) Generating at least 10 truncated constructs
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