重组人Galectin-3北京现货

特别提示：包括重组人Galectin-3在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人Galectin-3
英文名称：Recombinant Human Galectin-3
产品货号：GS4753
产品规格：10μg

分子量：Approximately 26.0kDa,a single non-glycosylated polypeptide chain containing 249 amino acids.
储存条件：冷冻（-20℃）

概述

Human Galectin-3 also named AGE-R3,CBP35,GAL3,L29,LGALS3,Mac-2,is belonging to the galectins family and it is encoded by a single gene,LGALS3,located on chromosome 14,locus q21–q22.It is expressed in the nucleus,cytoplasm,mitochondrion,cell surface,and extracellular space.Galectin-3 is approximately 30 kDa and,like all galectins,contains a carbohydrate-recognition-binding domain(CRD)of about 130 amino acids that enable the specific binding of β-galactosides.Given Galectin-3’s broad biological functionality,it has been demonstrated to be involved in cancer,inflammation and fibrosis,heart disease,and stroke.Studies have also shown that the expression of galectin-3 is implicated in a variety of processes associated with heart failure,including myofibroblast proliferation,fibrogenesis,tissue repair,inflammation,and Ventricular remodeling.Human Galectin-3 shares 79%amino acid sequence identity with rat and mouse Galectin-3,respectively.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞98%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by its ability to agglutinate human red blood cells is less than 10μg/ml.
成分	Lyophilized from a 0.2μmfiltered solution in 1×PBS,pH 7.4,3mMDTT.
内毒素	Less than 0.1 EU/μg of rHuGalectin-3 as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	ADNFSLHDAL SGSGNPNPQG WPGAWGNQPA GAGGYPGASY PGAYPGQAPP GAYPGQAPPG AYPGAPGAYP GAPAPGVYPG PPSGPGAYPS SGQPSATGAY PATGPYGAPA GPLIVPYNLP LPGGVVPRML ITILGTVKPN ANRIALDFQR GNDVAFHFNP RFNENNRRVI VCNTKLDNNW GREERQSVFP FESGKPFKIQ VLVEPDHFKV AVNDAHLLQY NHRVKKLNEI SK

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