Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
英文名:
Human Galectin-9 Protein, His Tag
库存:
999
供应商:
卡梅德生物科技(天津)有限公司
规格:
10ug/50ug
规格:
10ug
产品价格:
¥1152.0
规格:
50ug
产品价格:
¥3200.0
产品编号: KMP2391产品名称: Human Galectin-9 Protein, His Tag中文名称: 重组人Galectin-9 Protein蛋白中文全称: 重组人半乳糖凝集素蛋白关键词: 半乳糖凝集素, Galectin-9, Lgals9, Gal-9, Human Galectin-9 Protein, His Tag, Recombinant Protein, KMP2391物种: Human宿主: HEK293 Cells规格: 50ug, 100ug, 200ug纯化方式: Affinity purification纯度: >95% as determined by SDS-PAGE内毒素水平: <1.0 EU/ug determined by the LAL method缓冲体系: 50mM MOPS, 150mM NaCl, 1mM DTT, 1mM EDTA, 5% Trehalose, pH7.4Uniprot: O00182SDS-PAGE: KMP2391 SDS-PAGE image1.png功能: Binds galactosides (PubMed:18005988).Has high affinity for the Forssman pentasaccharide (PubMed:18005988).Ligand for HAVCR2/TIM3 (PubMed:16286920).Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (PubMed:16286920).Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity).Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307).Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity).Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (PubMed:23817958).Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection (PubMed:20209097).Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells (PubMed:24465902, PubMed:16116184).Inhibits degranulation and induces apoptosis of mast cells (PubMed:24465902).Induces maturation and migration of dendritic cells (PubMed:25754930, PubMed:16116184).Inhibits natural killer (NK) cell function (PubMed:23408620).Can transform NK cell phenotype from peripheral to decidual during pregnancy (PubMed:25578313).Astrocyte derived galectin-9 enhances microglial TNF production (By similarity).May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (By similarity).Highly selective to the anion urate (By similarity).Acts as an eosinophil chemoattractant (PubMed:9642261).It also inhibits angiogenesis (PubMed:24333696).Suppresses IFNG production by natural killer cells (By similarity).产品背景: Galectin-9 is a cytoplasmic protein that contains two galectin domains. Galectin-9 is an S-type lectin that is over-expressed in Hodgkin's disease tissue. Galectin-9 binds galactosides and has high affinity for the Forssman pentasaccharide. Galectin-9 plays a role in thymocyte-epithelial interactions relevant to the biology of the thymus and Inhibits cell proliferation. Galectin-9 is a ligand for HAVCR2/TIM3 and induces T-helper type 1 lymphocyte(Th1) death. In addition, Galectin-9 suppresses tumor cell metastasis by interfering with the associations CD44, VCAM-1, Integrin α4β1.保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.说明: This product is for research use only.官网链接: https://www.kmdbioscience.cn/参考文献: 1.J. Immunol. 175:2974-2981 (2005)2.Nat. Immunol. 6:1245-1252 (2005)3.J. Mol. Biol. 375:119-135 (2008)4.Glycobiology 19:112-117 (2009)5.PLoS ONE 5:E9504-E9504 (2010)6.Proc. Natl. Acad. Sci. U.S.A. 108:10650-10655 (2011)7.J. Virol. 87:4835-4845 (2013)8.Eur. J. Immunol. 43:2741-2749 (2013)9.PLoS ONE 9:E86106-E86106 (2014)10.Cell. Mol. Immunol. 13:73-81 (2016)11.J. Cell. Mol. Med. 19:1065-1076 (2015)12.Biochim. Biophys. Acta 1842:284-292 (2014)13.J. Biol. Chem. 273:16976-16984 (1998)