- ￥5832.53
- nsjbio
- V3932-100UG
- 2025年07月15日
- Mouse
- Human; Other species not tested.
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
A portion of amino acids 685-804 from the human protein was used as the immunogen for the Thyroid Peroxidase antibody.
- 亚型：
Mouse IgG1, kappa
- 克隆性：
单克隆
- 适应物种：
Human; Other species not tested.
- 宿主：
Mouse
- 规格：
100ug
Primary antibody
纯化方法：
Purified
通用信息：
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
产品描述：
Thyroperoxidase (TPO) is a 933-amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.
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文献和实验Methods for the Investigation of Thyroid Function
of free thyroxine. An equilibrium dialysis method is described. Methods for the measurement of TSH receptor antibodies and for thyroid peroxidase and thyroglobulin antibodies used in the assessment of autoimmune thyroid disease are given.
The Peroxidase-Antiperoxidase (PAP) Method
-antibody solution, the PAP immune complex. The horseradish peroxidase enzyme, itself an immunogenic protein, is used to inoculate a given species, and a polyclonal immune response is generated against the enzyme. This antiserum is harvested and placed
Conjugation of Antibodies to Horseradish Peroxidase
Horseradish peroxidase is coupled to IgG antibody in a two-step procedure. In the first step monosaccharide residues in the enzyme are oxidized with periodate to produce aldehyde groups. Then, in the second step, the aldehyde groups
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