LIT-001,2245072-20-0

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LIT-001 free base

CAS No. : 2245072-20-0

MCE 国际站：LIT-001 free base

产品活性：LIT-001 free base 是第一种非肽类催产素受体 (OT-R) 激动剂 (EC₅₀=55 nM; K_i=226 nM)。LIT-001 free base 改善孤独症小鼠模型的社交互动。

研究领域：GPCR/G Protein

作用靶点：Oxytocin Receptor

In Vitro: In vitro signaling experiments, LIT-001 free base is a nonbiased OT-R agonist on the two main signaling pathways of this receptor, with minor antagonist effect on V1a and agonist effect on V1b receptors, observed at high concentrations only.

In Vivo: LIT-001 free base (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD ).

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