重组人中性粒细胞明胶酶相关脂质运载蛋白(NGAL)(LCN2

特别提示：包括重组人中性粒细胞明胶酶相关脂质运载蛋白(NGAL)(LCN2)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人中性粒细胞明胶酶相关脂质运载蛋白(NGAL)(LCN2)
英文名称：Recombinant Human Neutrophil gelatinase-associated lipocalin
产品货号：JN1186
产品规格：10μg|50μg|500μg|1mg

本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Gln21-Gly198在C端含有His标签。

LCN2质量控制：＞95%(还原性SDS-PAGE)

LCN2制剂：液体

LCN2保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于LCN2：
Neutrophil gelatinase-associated lipocalin(LCN2) is a secreted protein and belongs to the calycin superfamily. This protein is released from injured tubular cells after various damaging stimuli, is already known by nephrologists as one of the most promising biomarkers of incoming Acute Kidney Injury (AKI). Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions. Moreover, recent studies seem to suggest a potential involvement of this factor also in the genesis and progression of chronic kidney diseases. NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores, which are high-affinity iron chelators. NGAL, first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation, NGAL has a clear pro-tumoral effect, as has already been observed in different tumors (e.g. breast, stomach, oesophagus, brain) in humans. In thyroid carcinomas, NGAL is strongly induced by NF-kB, an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development. Thus, Lipocalin-2 (LCN2/NGAL) has been implicated in a variety of processes including cell differentiation, proliferation, survival and morphogenesis.

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