- $495
- Leading Biology
- United States
- APR12953G
- 2025年07月11日
- Rabbit
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
Rabbit IgG
- 保存条件：
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
- 库存：
100
- 宿主：
Rabbit
- 靶点：
Procathepsin K
- 规格：
100 μl
37104 Da
细胞定位：
Antigen Cellular Localization: Lysosome.
形式：
100 μg (0.5 mg/ml) of antibody in PBS pH 7.2 containing 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol.
参考文献：
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Procathepsin K antibody.
功能：
Important for the overall degradation of proteins in lysosomes.
总结：
Cathepsin K, a member of the papain cysteine proteinase family, is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996). Cathepsin K is produced as an inactive proenzyme (35.4 kDa) that is converted to its mature active form (23.5 kDa) by proteolytic cleavage of its 99-amino-acid propeptide domain. The in-vitro processing of Procathepsin K to mature Cathepsin K is autocatalytic.
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