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ALKBH8 Antibody (C-term) [APR0

5806G]
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  • ¥1375 - 5000
  • Leading Biology
  • APR05806G
  • 美国
  • 2025年10月01日
  • IHC-P, FC, WB
  • Rabbit
  • H
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 靶点

      Alkylated DNA repair protein alkB homolog 8, 11411-, Probable alpha-ketoglutarate-dependent dioxygenase ABH8, S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8, tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8, ALKBH8, ABH8

    • 浓度

      Affinity Purification

    • 应用范围

      IHC-P, FC, WB

    • 宿主

      Rabbit

    • 适应物种

      H

    • 保质期

      1-2年

    • 供应商

      安诺伦(北京)生物科技有限公司

    • 克隆性

      Polyclonal

    • 保存条件

      Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

    • 形态

      Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    • 免疫原

      This ALKBH8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 494-523 amino acids from the C-terminal region of human ALKBH8.

    • 规格

      400 µl/200 µl/100 µl/50 µl

    规格:400 µl产品价格:¥5000.0
    规格:200 µl产品价格:¥3250.0
    规格:100 µl产品价格:¥2250.0
    规格:50 µl产品价格:¥1375.0
    分子量:75208

    细胞定位:Cytoplasm. Nucleus Note=Predominantly cytoplasmic.

    功能:Catalyzes the methylation of 5-carboxymethyl uridine to 5- methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323, PubMed:31079898). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)- methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182).

    总结:Tissue Location: Widely expressed, with highest expression in spleen, followed by pancreas and lung.

    稀释方法:WB--1:1000 IHC-P--1:100~500 FC--1:10~50

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    ALKBH8 Antibody (C-term) [APR05806G]
    ¥1375 - 5000