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CDKN1A Antibody (C-term) [APR0

3821G]
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  • ¥1375 - 5000
  • Leading Biology
  • APR03821G
  • 美国
  • 2025年09月25日
  • WB, IF, IHC-P
  • Rabbit
  • H, M
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 靶点

      Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, MDA-6, p21, CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1

    • 浓度

      Affinity Purification

    • 应用范围

      WB, IF, IHC-P

    • 宿主

      Rabbit

    • 适应物种

      H, M

    • 保质期

      1-2年

    • 供应商

      安诺伦(北京)生物科技有限公司

    • 克隆性

      Polyclonal

    • 保存条件

      Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

    • 形态

      Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

    • 免疫原

      This CDKN1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 117-146 amino acids from the C-terminal region of human CDKN1A.

    • 规格

      400 µl/200 µl/100 µl/50 µl

    规格:400 µl产品价格:¥5000.0
    规格:200 µl产品价格:¥3250.0
    规格:100 µl产品价格:¥2250.0
    规格:50 µl产品价格:¥1375.0
    分子量:18119

    细胞定位:Cytoplasm. Nucleus

    功能:May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin- dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D- CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). Plays an important role in controlling cell cycle progression and DNA damage- induced G2 arrest (PubMed:9106657).

    总结:Tissue Location: Expressed in all adult tissues, with 5-fold lower levels observed in the brain

    稀释方法:WB--1:1000

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