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- 详细信息
- 文献和实验
- 技术资料
- 靶点:
Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, MDA-6, p21, CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1
- 浓度:
Affinity Purification
- 应用范围:
WB, IF, IHC-P
- 宿主:
Rabbit
- 适应物种:
H, M
- 保质期:
1-2年
- 供应商:
安诺伦(北京)生物科技有限公司
- 克隆性:
Polyclonal
- 保存条件:
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
- 形态:
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原:
This CDKN1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 117-146 amino acids from the C-terminal region of human CDKN1A.
- 规格:
400 µl/200 µl/100 µl/50 µl
| 规格: | 400 µl | 产品价格: | ¥5000.0 |
|---|---|---|---|
| 规格: | 200 µl | 产品价格: | ¥3250.0 |
| 规格: | 100 µl | 产品价格: | ¥2250.0 |
| 规格: | 50 µl | 产品价格: | ¥1375.0 |
细胞定位:Cytoplasm. Nucleus
功能:May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin- dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D- CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). Plays an important role in controlling cell cycle progression and DNA damage- induced G2 arrest (PubMed:9106657).
总结:Tissue Location: Expressed in all adult tissues, with 5-fold lower levels observed in the brain
稀释方法:WB--1:1000
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文献和实验于研究。 性能参数 LIST OF ANTBODY PRODUCTS AP8401a BDP1 N-term Antibody AP8408b MEG2 C-term Antibody AP8451b PPP3CA C-term Antibody AP8449b CTDSP1 C-term Antibody AP8408a MEG2 N-term Antibody AP8451a PPP3CA N-term Antibody AP8449
Interaction Trap/Two‐Hybrid System to Identify Interacting Proteins
of interest Plasmids (see Table 4.4.1 ): e.g., pEG202 (Fig. ), pSH18‐34 (Fig. ), pSH17‐4, pRFHM1 Yeast strain: e.g., EGY48 (ura3 trp1 his3 3LexA ‐operator‐LEU2 ; see Table
【资源】全面归类网址:毕赤酵母表达各种来源蛋白(细菌,真菌,植物,人类等)
Heterologous Proteins Expressed in Pichia pastoris有以下几部分组成:Protein CommentsMode, amount,signal sequenceReferences and Links分别分物种来源如下:BacteriaAlpha galactosidaseS453Bacillus licheniformis alpha-amylaseS, 2.5 g/L, SUC2[53, 54]Bacillus
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