- $495
- Leading Biology
- United States
- APG01270G
- 2025年07月16日
- Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
Mouse / IgG2b, kappa
- 保存条件：
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
- 克隆性：
单克隆
- 库存：
100
- 宿主：
Mouse
- 抗体名：
G250, MN
- 规格：
7 ml
200kDa
细胞定位：
Antigen Cellular Localization: Nucleus. Nucleus, nucleolus. Cell membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Note=Found on the surface microvilli and in the nucleus, particularly in nucleolus
形式：
Liquid. In PBS containing 0.02% sodium azide.
参考文献：
Yoshida SO, et. al. Cancer Research, 1989, 49(7):1802-9
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Renal Cell Carcinoma / gp200 antibody.
功能：
Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.
总结：
Recognizes a glycoprotein of ~200kDa, identified as carbonic anhydrase IX (CAIX/gp200). Its epitope resides in the carbohydrate domain of gp200. It shows no significant cross-reactivity with other carbohydrate determinants, such as the Lewis blood group antigens, epithelial membrane antigen, HMFG, and AB blood group antigens. In normal kidney, gp200 is localized along the brush border of the pars convoluta and pars recta segments of the proximal tubule, as well as focally along the luminal surface of Bowman's capsule adjoining the outgoing proximal tubule. Reportedly, gp200 is expressed by 93% of primary and 84% of metastatic renal cell carcinomas. This MAb may be useful in the investigations of carcinomas of proximal nephrogenic differentiation especially those showing tubular differentiation.
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文献和实验Experimental Models and Methods in Antibody Targeting of Renal Cell Carcinoma
Metastatic renal cell carcinoma (RCC) is incurable and there are few treatment options that assure even a short prolongation in survival. It is the most common malignancy of the adult kidney and accounts for approximately 12,000 deaths per year
Orthotopic Model of Renal Cell Carcinoma
A human renal cancer was first established in continuous culture in 1962. Currently, there are well over 100 different characterized renal cancer cell lines derived from both primary and metastatic renal cell carcinomas (RCCs) (1 –
Detection of Apoptosis in Renal Cell Carcinoma
correlated with tumor grade, stage, and size in renal cell carcinoma (RCC) (1 ). Apoptosis is closely related to proliferative activity, tumor differentiation, and depth of invasion in transitional-cell carcinoma of the renal pelvis and ureter
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