Mouse TLR8 Antibody (C-term) [

分子量：119358

细胞定位：Endosome membrane {ECO:0000250|UniProtKB:Q9NR97}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9NR97} Note=Endosomal localization confers distinctive proteolytic processing {ECO:0000250|UniProtKB:Q9NR97}

功能：Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR- containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively.

稀释方法：WB--1:1000 IHC-P--1:100~500