- $495
- Leading Biology
- United States
- AMM06155G
- 2025年08月25日
- Rabbit
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
43-72 aa
- 亚型：
Rabbit Ig
- 保存条件：
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
- 库存：
100
- 宿主：
Rabbit
- 靶点：
This KCNMB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 43-72 amino acids from the Central region of human KCNMB1.
- 规格：
100 μl
21797 Da
细胞定位：
Antigen Cellular Localization: Membrane; Multi-pass membrane protein.
形式：
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献：
Bailey, S.D., et al. Diabetes Care (2010) In press : Xie, M.J., et al. Am. J. Physiol., Cell Physiol. 298 (6), C1489-C1500 (2010) : Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) : Long, X., et al. J. Biol. Chem. 284(48):33671-33682(2009) Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality KCNMB1 antibody (Center).
功能：
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.
总结：
MaxiK channels are large conductance, voltage andcalcium-sensitive potassium channels which are fundamental to thecontrol of smooth muscle tone and neuronal excitability. MaxiKchannels can be formed by 2 subunits: the pore-forming alphasubunit and the product of this gene, the modulatory beta subunit.Intracellular calcium regulates the physical association betweenthe alpha and beta subunits.
联系方式：
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文献和实验Double immunohistochemistry for BCL6 and PNA for Germinal Center detection.
(see Reagents and Solutions). 3- incubate with the blocking for 10 min. If one of your antibody is biotin-conjugated, you need at this point to do endogenous biotin blocking. 4- blot the slides without washing and apply the primary antibody, in a moist
Double immunohistochemistry for BCL6 and PNA for Germinal Center detection
Double immunohistochemistry for BCL6 and PNA for Germinal Center detection. (on fixed, paraffin-embedded sections) Cut sections at 4µm, use a clean water bath with distilled water, and let the sections dry
with those with a postgerminal center/activated profile. Microarray technology may not be available in many diagnostic laboratories, and antibody-based methods are much simpler and cheaper and are therefore more applicable to the routine setting. Immunocytochemistry
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