重组大鼠IL-1RA北京品牌

特别提示：包括重组大鼠IL-1RA在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组大鼠IL-1RA
英文名称：Recombinant Rat Interleukin-1 Receptor Antagonist Protein
产品货号：GS4575
产品规格：20μg

分子量：Approximately 17.4kDa,a single non-glycosylated polypeptide chain containing 152 amino acids.
储存条件：冷冻（-20℃）

概述

IL-1RA was initially called the IL-1 inhibitor which is encoded by the IL1RN gene and it is a member of the interleukin 1 cytokine family.IL-1RA is secreted by various types of cells including immune cells,epithelial cells,and adipocytes.IL-RA has functions of inhibiting the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the co-receptor IL1RAP for signaling.IL-1RA is also used in the treatment of rheumatoid arthritis,an autoimmune disease in which IL-1 plays a key role.The rat IL-1RA is a single non-glycosylated polypeptide chain containing 152 amino acids and it has been shown to block the inflammatory responses induced by IL-1 both in vitro and in vivo.Rat IL-1RA shares 89%and 73%a.a.sequence homology with murine and human IL-1RA.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞96%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by inhibiting IL-1α-dependent proliferation of murine D10S cells is less than 150ng/ml,corresponding to a specific activity of>6.7×103 IU/mg in the presence of 50pg/ml rRtIL-1α.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rRtIL-1RA as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	HPAGKRPCKM QAFRIWDTNQ KTFYLRNNQL IAGYLQGPNT KLEEKIDMVP IDFRNVFLGI HGGKLCLSCV KSGDDTKLQL EEVNITDLNK NKEEDKRFTF IRSETGPTTS FESLACPGWF LCTTLEADHP VSLTN*PKEP CTVTKFYFQE DQ

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